{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:02:52Z","timestamp":1792670572330,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2009,9,22]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Tricuspid regurgitation in hypoplastic left heart syndrome has an impact on outcome, but its mechanisms remain unclear.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Real-time 3-dimensional echocardiography was performed in 35 patients with hypoplastic left heart syndrome (age, 1 month to 10 years; 10 after first-stage Norwood, 12 after superior cavopulmonary shunt, 13 after Fontan). From the 3-dimensional data set, we marked the annulus in systole and diastole. At mid systole, we marked the location of the papillary muscle tip and point of chordal attachment to the leaflet. We traced the surfaces of the tricuspid valve leaflets and measured the volume of leaflet prolapse, tethering, annular and septal leaflet areas, and papillary muscle position. Seventeen patients had moderate tricuspid regurgitation (prolapse, 7; tethered leaflets, 7) and 18 mild (prolapse, 0; tethered leaflets, 7). Multiple linear regression analysis revealed that moderate tricuspid regurgitation is associated with leaflet tethering and prolapse; that in hypoplastic left heart syndrome with tethered leaflets, the papillary muscle is displaced laterally and the tricuspid annulus is more planar; and that enlargement of the annulus at mid systole, small septal leaflet area, and age affect the degree of prolapse.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            In hypoplastic left heart syndrome, moderate tricuspid regurgitation may be associated with increasing age, geometrical changes of the annulus, leaflet prolapse, lateral papillary muscle displacement, and subsequent leaflet tethering, as well as a smaller septal leaflet.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.108.809566","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T02:19:33Z","timestamp":1252462773000},"page":"1091-1098","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Real-Time 3-Dimensional Echocardiography Provides New Insight Into Mechanisms of Tricuspid Valve Regurgitation in Patients With Hypoplastic Left Heart Syndrome"],"prefix":"10.1161","volume":"120","author":[{"given":"K.","family":"Takahashi","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Inage","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Rebeyka","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Ross","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Mackie","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Smallhorn","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics, Surgery and Biomedical Engineering, University of Alberta, and Stollery Children\u2019s Hospital Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032878.55215.bd"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.07.053"},{"key":"e_1_3_2_3_2","first-page":"341","volume":"96","year":"1997","unstructured":"Reyes A, Bove EL, Mosca RS, Kulik TJ, Ludomirsky A. Tricuspid valve repair in children with hypoplastic left heart syndrome during staged surgical reconstruction. Circulation. 1997; 96 (suppl): 341\u2013345.","journal-title":"Circulation"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90744-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90845-Z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.001305"},{"key":"e_1_3_2_7_2","first-page":"975","volume":"111","year":"2006","unstructured":"Fukuda S, Song JM, Gillinov, McCarthy PM, Daimon M, Kongsaerepong V, Thomas JD, Shiota T. Tricuspid valve tethering predicts residual tricuspid regurgitation after tricuspid annuloplasty. 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