{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:53:50Z","timestamp":1780970030697,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2009,6,30]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Whether triple antiplatelet therapy is superior or similar to dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention in the era of drug-eluting stents remains unclear.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A total of 4203 ST-segment elevation myocardial infarction patients who underwent primary percutaneous coronary intervention with drug-eluting stents were analyzed retrospectively in the Korean Acute Myocardial Infarction Registry (KAMIR). They received either dual (aspirin plus clopidogrel; dual group; n=2569) or triple (aspirin plus clopidogrel plus cilostazol; triple group; n=1634) antiplatelet therapy. The triple group received additional cilostazol at least for 1 month. Various major adverse cardiac events at 8 months were compared between these 2 groups. Compared with the dual group, the triple group had a similar incidence of major bleeding events but a significantly lower incidence of in-hospital mortality. Clinical outcomes at 8 months showed that the triple group had significantly lower incidences of cardiac death (adjusted odds ratio, 0.52; 95% confidence interval, 0.32 to 0.84;\n            <jats:italic>P<\/jats:italic>\n            =0.007), total death (adjusted odds ratio, 0.60; 95% confidence interval, 0.41 to 0.89;\n            <jats:italic>P<\/jats:italic>\n            =0.010), and total major adverse cardiac events (adjusted odds ratio, 0.74; 95% confidence interval, 0.58 to 0.95;\n            <jats:italic>P<\/jats:italic>\n            =0.019) than the dual group. Subgroup analysis showed that older (&gt;65 years old), female, and diabetic patients got more benefits from triple antiplatelet therapy than their counterparts who received dual antiplatelet therapy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Triple antiplatelet therapy seems to be superior to dual antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stents. These results may provide the rationale for the use of triple antiplatelet therapy in these patients.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.108.822791","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T01:30:00Z","timestamp":1245115800000},"page":"3207-3214","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":169,"title":["Triple Versus Dual Antiplatelet Therapy in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"119","author":[{"given":"Kang-Yin","family":"Chen","sequence":"first","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jian","family":"Li","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanhaiya L.","family":"Poddar","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Minami","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Seog","family":"Seo","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joo","family":"Oh","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Keun","family":"Ahn","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek Jong","family":"Hong","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Whan","family":"Seong","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jei Keon","family":"Chae","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Chan","family":"Cho","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Ho","family":"Bae","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Soo","family":"Jang","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ho","family":"Chae","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han","family":"Yoon","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook Sung","family":"Chung","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Bae","family":"Seung","sequence":"additional","affiliation":[{"name":"From the Korea University Guro Hospital, Seoul, 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