{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:32Z","timestamp":1792008092692,"version":"4.4.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2009,8,25]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Trait optimism (positive future expectations) and cynical, hostile attitudes toward others have not been studied together in relation to incident coronary heart disease (CHD) and mortality in postmenopausal women.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Participants were 97 253 women (89 259 white, 7994 black) from the Women\u2019s Health Initiative who were free of cancer and cardiovascular disease at study entry. Optimism was assessed by the Life Orientation Test\u2013Revised and cynical hostility by the cynicism subscale of the Cook Medley Questionnaire. Cox proportional hazard models produced adjusted hazard ratios (AHRs) for incident CHD (myocardial infarction, angina, percutaneous coronary angioplasty, or coronary artery bypass surgery) and total mortality (CHD, cardiovascular disease, or cancer related) over \u22488 years. Optimists (top versus bottom quartile [\u201cpessimists\u201d]) had lower age-adjusted rates (per 10 000) of CHD (43 versus 60) and total mortality (46 versus 63). The most cynical, hostile women (top versus bottom quartile) had higher rates of CHD (56 versus 44) and total mortality (63 versus 46). Optimists (versus pessimists) had a lower hazard of CHD (AHR 0.91, 95% CI 0.83 to 0.99), CHD-related mortality (AHR 0.70, 95% CI 0.55 to 0.90), cancer-related mortality (blacks only; AHR 0.56, 95% CI 0.35 to 0.88), and total mortality (AHR 0.86, 95% CI 0.79 to 0.93). Most (versus least) cynical, hostile women had a higher hazard of cancer-related mortality (AHR 1.23, 95% CI 1.09 to 1.40) and total mortality (AHR 1.16, 95% CI 1.07 to 1.27; this effect was pronounced in blacks). Effects of optimism and cynical hostility were independent.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Optimism and cynical hostility are independently associated with important health outcomes in black and white women. Future research should examine whether interventions designed to change attitudes would lead to altered risk.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.108.827642","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T01:28:49Z","timestamp":1249954129000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":350,"title":["Optimism, Cynical Hostility, and Incident Coronary Heart Disease and Mortality in the Women\u2019s Health Initiative"],"prefix":"10.1161","volume":"120","author":[{"given":"Hilary A.","family":"Tindle","sequence":"first","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Fang","family":"Chang","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis H.","family":"Kuller","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros C.","family":"Rosal","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Siegle","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Matthews","sequence":"additional","affiliation":[{"name":"From the University of Pittsburgh (H.A.T., Y.-F.C., L.H.K., G.J.S., K.A.M.), Pittsburgh, Pa; Brigham and Women\u2019s Hospital and Harvard Medical School (J.E.M.), Boston, Mass; University of Iowa (J.G.R.), Iowa City, Iowa; and University of Massachusetts (M.C.R.), Worcester, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.4.818"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000105766.33142.13"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61415-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17019-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31818105ba"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.6.1063"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.8.829"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.11.1126"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.092"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.26.6.675"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117663"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00043-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00042-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198808000-00004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00048-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.18.1837"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116381"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90542-W"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.574087"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030808"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-2-199707150-00003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(97)00053-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.76.1.104"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199809000-00021"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000139999.99756.a5"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.04.010"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.12.027"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1257"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.91.1.143"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.14.3.210"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15324796abm2901_6"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06280"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(00)00100-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.66.1.7083525"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02194-4"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1626"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3106"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.6.701"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.108.827642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:30:40Z","timestamp":1715578240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.108.827642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,25]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8,25]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.108.827642"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.108.827642","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,25]]},"assertion":[{"value":"2009-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}