{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:08:06Z","timestamp":1773407286441,"version":"3.50.1"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,5,18]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    At present, no medical therapy is known to affect the progression of rheumatic mitral stenosis (MS). We sought to assess the effect of statin treatment on long-term progression of MS in a large population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    From our 20-year database, we identified all patients with rheumatic MS with \u22652 echocardiographies \u22651 year apart. Exclusion criteria were previous intervention on the mitral valve, more than moderate aortic regurgitation, or symptoms at first examination. The study sample included 315 patients (mean age, 61\u00b112 years; 224 women); 35 patients (11.1%) were treated with statins, and 280 (88.9%) were not. Mean follow-up period was 6.1\u00b14.0 years (range, 1 to 20). The rate of decrease in mitral valve area was significantly lower in the statin group compared with the untreated group (0.027\u00b10.056 versus 0.067\u00b10.082 cm\n                    <jats:sup>2<\/jats:sup>\n                    \/y;\n                    <jats:italic>P<\/jats:italic>\n                    =0.005). The annualized change in mean transmitral gradient was lower in statin-treated patients (0.20\u00b10.59 versus 0.58\u00b10.96 mm Hg\/y;\n                    <jats:italic>P<\/jats:italic>\n                    =0.023). The prevalence of fast MS progression (annual change in mitral valve area &gt;0.08 cm\n                    <jats:sup>2<\/jats:sup>\n                    ) was significantly lower in the statin group (\n                    <jats:italic>P<\/jats:italic>\n                    =0.008). An increase in systolic pulmonary artery pressure of &gt;10 mm Hg was found in 17% of patients in the statin group versus 40% of untreated patients (\n                    <jats:italic>P<\/jats:italic>\n                    =0.045).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Our study shows a significantly slower progression of rheumatic MS in patients treated with statins. These findings could have an important impact in the early medical therapy of patients with rheumatic heart disease.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.109.891598","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T22:23:19Z","timestamp":1272925399000},"page":"2130-2136","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of Hydroxymethylglutaryl Coenzyme-A Reductase Inhibitors on the Long-Term Progression of Rheumatic Mitral Valve Disease"],"prefix":"10.1161","volume":"121","author":[{"given":"Francesco","family":"Antonini-Canterin","sequence":"first","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Moura","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Enache","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Leiballi","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pavan","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Piazza","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan A.","family":"Popescu","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ginghina\u0306","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Luigi","family":"Nicolosi","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini M.","family":"Rajamannan","sequence":"additional","affiliation":[{"name":"From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66874-2"},{"key":"e_1_3_2_2_2","unstructured":"Rheumatic Fever and Rheumatic Heart Disease: Report of WHO Expert Consultation Geneva 29 October--1 November 2001. Geneva Switzerland: World Health Organization; 2004. 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Ongoing clinical trial of the pleiotropic effects of statins. 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Medical therapy for rheumatic heart disease: is it time to be proactive rather than reactive? 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