{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:48:54Z","timestamp":1790740134122,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,7,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Stent thrombosis (ST) after sirolimus-eluting stent implantation has not yet been adequately characterized, mainly because of its low incidence.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The Registry of Stent Thrombosis for Review and Reevaluation (RESTART) is a Japanese nationwide registry of sirolimus-eluting stent\u2013associated ST comprising 611 patients with definite ST (early [within 30 days; EST], 322 patients; late [between 31 and 365 days; LST], 105 patients; and very late [&gt;1 year; VLST], 184 patients). Baseline demographics, clinical presentation, and long-term outcome of sirolimus-eluting stent\u2013associated ST were compared among patients with EST, LST, and VLST. Baseline demographics were significantly different according to the timing of ST. Characteristic demographic factors for LST\/VLST versus EST identified by multivariable model were hemodialysis, end-stage renal disease not on hemodialysis, absence of circumflex target, target of chronic total occlusion, prior percutaneous coronary intervention, and age &lt;65 years. For LST versus VLST, they were hemodialysis, heart failure, insulin-dependent diabetes mellitus, and low body mass index. Patients with LST had a significantly higher rate of Thrombolysis in Myocardial Infarction grade 2\/3 flow (36%) at the time of ST than those with EST (13%) (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) and VLST (17%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). Mortality rate at 1 year after ST was significantly lower in patients with VLST (10.5%) compared with those with EST (22.4%;\n            <jats:italic>P<\/jats:italic>\n            =0.003) or LST (23.5%;\n            <jats:italic>P<\/jats:italic>\n            =0.009).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            ST timing\u2013dependent differences in baseline demographic features, Thrombolysis in Myocardial Infarction flow grade, and mortality rate suggest possible differences in the predominant pathophysiological mechanisms of ST according to timing after sirolimus-eluting stent implantation.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.109.903955","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T02:48:06Z","timestamp":1277174886000},"page":"52-61","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":213,"title":["Comparisons of Baseline Demographics, Clinical Presentation, and Long-Term Outcome Among Patients With Early, Late, and Very Late Stent Thrombosis of Sirolimus-Eluting Stents"],"prefix":"10.1161","volume":"122","author":[{"given":"Takeshi","family":"Kimura","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Honda","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Kume","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanori","family":"Aizawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Mitsudo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Hiyoshi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. Kume); Division of Cardiology, Cardiovascular Institute Hospital, Tokyo, Japan (T.A.); Division of Cardiology, Kurashiki Central..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Isshiki","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular of Medicine (T. Kimura) and Center for Medical Education and Clinical Epidemiology Unit (T.M.), Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Cardiology, Teikyo University Hospital, Teikyo, Japan (K.K., T.I.); Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif (Y.H., T. 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