{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:09:54Z","timestamp":1791194994038,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,7,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional aortic valve replacement. The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry was designed to assess the initial clinical results of the Edwards SAPIEN valve in consecutive patients in Europe after commercialization. Cohort 1 consists of 1038 patients enrolled at 32 centers. Patients who were treated with the transapical approach (n=575) suffered more comorbidities than the transfemoral patients (n=463), resulting in a significantly higher logistic EuroSCORE (29.1% versus 25.7%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Therefore, these groups are considered different, and outcomes cannot be compared. Overall short-term procedural success was observed in 93.8%. The incidence of valve embolization was 0.3% (n=3), and coronary obstruction was reported for 0.6% (n=6 cases). Incidence of stroke was 2.5% and similar for both procedural approaches. Thirty-day mortality was 6.3% in transfemoral patients and 10.3% in transapical patients. The occurrence of vascular complications was not a predictor of &lt;30-day mortality in the transfemoral population.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Technical proficiency can be learned and adapted readily as demonstrated by the short-term procedural success rate and low 30-day mortality rates reported in the SOURCE Registry. Specific complication management and refinement of patient selection are needed to further improve outcomes.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.109.907402","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T02:48:06Z","timestamp":1277174886000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":735,"title":["Thirty-Day Results of the SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry"],"prefix":"10.1161","volume":"122","author":[{"given":"Martyn","family":"Thomas","sequence":"first","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schymik","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Himbert","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lefe\u0300vre","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Treede","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Eggebrecht","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rubino","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iassen","family":"Michev","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u0308diger","family":"Lange","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Wendler","sequence":"additional","affiliation":[{"name":"From St Thomas\u2019 Hospital, London, UK (M.T.); Sta\u0308disches Klinikum und Herzklinik, Karlsruhe, Germany (G.S.); Herzzentrum, Leipzig, Germany (T.W.); Ho\u0302pital Bichat, Paris, France (D.H.); Jacques Cartier, Massy, France (T.L.); University Heart Center, Hamburg, Germany (H.T.); Uniklinik, Essen, Germany (H.E.); Clinica Montevergine, Mercogliano, Italy (P.R.); Hospital San Raffaele, Milan, Italy (I.M.); Deutsches Herzzentrum, Munich, Germany; Lake Forest, Calif (W.N.A.); and King\u2019s College Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"1231","volume":"13","year":"2003","unstructured":"Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-B\u00e4rwolf C, Levang OW, Tornos P, Vanoverschelde JL, Vermeer F, Boersma E, Ravaud P, Vahanian A. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on valvular heart disease. Eur Heart J. 2003; 13: 1231\u20131243.","journal-title":"Eur Heart J"},{"key":"e_1_3_2_2_2","first-page":"e523","volume":"15","year":"2008","unstructured":"A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease 2008). Focused update incorporated into the ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease. Circulation. 2008; 15: e523\u2013e661.","journal-title":"Circulation"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa035205"},{"key":"e_1_3_2_4_2","first-page":"468","volume":"2","year":"2009","unstructured":"Wendt D, Osswald BR, Kayeser K, Thielmann M, Tossios P, Massoudy P, Kamler M, Jakob H. STS score is superior to the EuroSCORE in determining mortality in high risk patients undergoing isolated aortic valve replacement. Ann Thorac Surg. 2009; 2: 468\u2013474.","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_2_5_2","first-page":"S23","volume":"1","year":"2009","unstructured":"O'Brien SM, Shahian DM, Filardo G, Ferraris VA, Haan CK, Rich JB, Normand SL, DeLong ER, Shewan CM, Dokholyan RS, Peterson ED, Edwards FH, Anderson RP, for the Society of Thoracic Surgeons Quality Measurement Task Force. The Society of Thoracic Surgeons 2008 Cardiac Surgery risk models, part 2: isolated valve surgery. Ann Thorac Surg. 2009; 1 (suppl): S23\u2013S42.","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-4-32"},{"key":"e_1_3_2_9_2","first-page":"1440","volume":"5","year":"2009","unstructured":"Leontyev S, Walther T, Borger MA, Lehmann S, Funkat AK, Rastan A, Kempfert J, Falk V, Mohr FW. Aortic valve replacement in octogenarians: utility of risk stratification with EuroSCORE. Ann Thorac Surg. 2009; 5: 1440\u20131445.","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00528-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000047200.36165.b8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.582882"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.01.046"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.04.049"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.2.8313553"},{"key":"e_1_3_2_16_2","unstructured":"Sch\u00e4chinger V Lefevre T de Bruyne B Nataf P Kappetein P Wimmer-Greinecker G. Results from the PARTNER EU trial: primary endpoint analysis: Prospective Multicentric European Registry of Transcatheter Aortic Valve Implantation. Presented at: EuroPCR; 2009; Barcelona Spain. Available at: http:\/\/www.europcronline.com. Accessed February 1 2010."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.837807"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn523"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.011"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00134-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2007.12.009"},{"key":"e_1_3_2_22_2","first-page":"108","volume":"1","year":"2008","unstructured":"Dawkins S, Hobson AR, Kalra PR, Tang A, Monro JL, Dawkins KD. Permanent pacemaker implantation after isolated aortic valve replacement: incidence, indications and predictors. Ann Thorac Surg. 2008; 1: 108\u2013112.","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.819839"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.02298.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.12.041"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2008.03.010"},{"key":"e_1_3_2_27_2","unstructured":"Rod\u00e9s-Cabau J. First report: the multi-center Canadian experience with Edwards SAPIEN TAVI: late follow-up in 339 patients. Presented at: TCT; 2009; San Francisco Calif. Available at: http:\/\/www.tcd.com. Accessed February 1 2010."},{"key":"e_1_3_2_28_2","unstructured":"Kodali S. Pooled analysis with extended follow-up from the REVIVE II and REVIVAL II transfemoral feasibility registries. Paper presented at: Transcatheter Cardiovascular Therapeutics; October 13 2008; Washington DC."},{"key":"e_1_3_2_29_2","first-page":"1463","volume":"11","year":"2008","unstructured":"Vahanian A, Alfieri O, Al-Attar N, Antunes M, Bax J, Cormier B, Cribier A, De Jaegere P, Fournial G, Kappetein AP, Kovac J, Ludgate S, Maisano F, Moat N, Mohr F, Nataf P, Pierard L, Pomar JL, Schofer J, Tornos P, Tuzcu M, van Hout B, Von Segesser LK, Walther T. Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2008; 11: 1463\u20131470.","journal-title":"Eur Heart J"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I1A4"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.109.907402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:35:21Z","timestamp":1715578521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.109.907402"}},"subtitle":["A European Registry of Transcatheter Aortic Valve Implantation Using the Edwards SAPIEN Valve"],"short-title":[],"issued":{"date-parts":[[2010,7,6]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7,6]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.109.907402"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.109.907402","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,6]]},"assertion":[{"value":"2010-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}