{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:35:43Z","timestamp":1760027743501},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,8,3]]},"abstract":"\n \n Background\u2014<\/jats:italic>\n <\/jats:bold>\n Lead V\n 1<\/jats:sub>\n directly faces the right ventricle and may exhibit ST elevation during an acute inferior myocardial infarction when the right ventricle is also involved. Leads V\n 1<\/jats:sub>\n and V\n 3<\/jats:sub>\n indirectly face the posterolateral left ventricle, and ST depression (\u201cmirror-image\u201d ST elevation) in V\n 1<\/jats:sub>\n through V\n 3<\/jats:sub>\n may reflect concomitant posterolateral infarction. The prognostic significance of V\n 1<\/jats:sub>\n ST elevation during an acute inferior myocardial infarction may therefore be dependent on V\n 3<\/jats:sub>\n ST changes.\n <\/jats:p>\n \n \n Methods and Results\u2014<\/jats:italic>\n <\/jats:bold>\n In 7967 patients with acute inferior myocardial infarction in the Hirulog and Early Reperfusion or Occlusion-2 (HERO-2) trial, V\n 1<\/jats:sub>\n ST levels were analyzed with adjustment for lead V\n 3<\/jats:sub>\n ST level for predicting 30-day mortality. V\n 1<\/jats:sub>\n ST elevation at baseline, analyzed as a continuous variable, was associated with higher mortality. Unadjusted, each 0.5-mm-step increase in ST level above the isoelectric level was associated with \u224825% increase in 30-day mortality; this was true whether V\n 3<\/jats:sub>\n ST depression was present or not. The odds ratio for mortality was 1.21 (95% confidence interval, 1.07 to 1.37) after adjustment for inferolateral ST elevation and clinical factors and 1.24 (95% confidence interval, 1.09 to 1.40) if also adjusted for V\n 3<\/jats:sub>\n ST level. In contrast, lead V\n 1<\/jats:sub>\n ST depression was not associated with mortality after adjustment for V\n 3<\/jats:sub>\n ST level. V\n 1<\/jats:sub>\n ST elevation \u22651 mm, analyzed dichotomously in all patients, was associated with higher mortality. The odds ratio was 1.28 (95% confidence interval, 1.01 to 1.61) unadjusted, 1.51 (95% confidence interval, 1.19 to 1.92) adjusted for V\n 3<\/jats:sub>\n ST level, and 1.35 (95% confidence interval, 1.04 to 1.76) adjusted for ECG and clinical factors. Persistence of V\n 1<\/jats:sub>\n ST elevation \u22651 mm 60 minutes after fibrinolysis was associated with higher mortality (10.8% versus 5.5%,\n P<\/jats:italic>\n =0.001).\n <\/jats:p>\n \n \n Conclusion\u2014<\/jats:italic>\n <\/jats:bold>\n V\n 1<\/jats:sub>\n ST elevation identifies patients with acute inferior myocardial infarction who are at higher risk.\n <\/jats:p>","DOI":"10.1161\/circulationaha.109.924068","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T04:50:30Z","timestamp":1279601430000},"page":"463-469","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Prognostic Value of Lead V\n 1<\/sub>\n ST Elevation During Acute Inferior Myocardial Infarction"],"prefix":"10.1161","volume":"122","author":[{"given":"Cheuk-Kit","family":"Wong","sequence":"first","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanzhen","family":"Gao","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"French","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"Aylward","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Benatar","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey D.","family":"White","sequence":"additional","affiliation":[{"name":"From the Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (C.K.W.); Division of Public Health and Psychosocial Studies, Akoranga Campus, Auckland University of Technology, Auckland, New Zealand (W.G.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (R.A.S., J.B., H.D.W.); Department of Cardiology, Liverpool Hospital, Sydney, Australia (J.K.F.); and Flinders Medical Centre, Adelaide, Australia (P.E.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.52.1.1132119"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01089-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.81.2.2404629"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90120-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00372-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123319"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01207-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.018"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06577-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06887-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi622"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.084"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68929-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.639039"},{"key":"e_1_3_2_15_2","first-page":"276","volume":"95","year":"2009","unstructured":"Wong CK, Gao W, Stewart RAH, French JK, Aylward PEG, White HD. 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