{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:42:27Z","timestamp":1791042147337,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,4,27]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The majority of prosthetic heart valves currently implanted are tissue valves that can be expected to degenerate with time and eventually fail. Repeat cardiac surgery to replace these valves is associated with significant morbidity and mortality. Transcatheter heart valve implantation within a failed bioprosthesis, a \u201cvalve-in-valve\u201d procedure, may offer a less invasive alternative.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Valve-in-valve implantations were performed in 24 high-risk patients. Failed valves were aortic (n=10), mitral (n=7), pulmonary (n=6), or tricuspid (n=1) bioprostheses. Implantation was successful with immediate restoration of satisfactory valve function in all but 1 patient. No patient had more than mild regurgitation after implantation. No patients died during the procedure. Thirty-day mortality was 4.2%. Mortality was related primarily to learning-curve issues early in this high-risk experience. At baseline, 88% of patients were in New York Heart Association functional class III or IV; at the last follow-up, 88% of patients were in class I or II. At a median follow-up of 135 days (interquartile range, 46 to 254 days) and a maximum follow-up of 1045 days, 91.7% of patients remained alive with satisfactory valve function.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Transcatheter valve-in-valve implantation is a reproducible option for the management of bioprosthetic valve failure. Aortic, pulmonary, mitral, and tricuspid tissue valves were amenable to this approach. This finding may have important implications with regard to valve replacement in high-risk patients.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.109.924613","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T23:54:51Z","timestamp":1271116491000},"page":"1848-1857","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":438,"title":["Transcatheter Valve-in-Valve Implantation for Failed Bioprosthetic Heart Valves"],"prefix":"10.1161","volume":"121","author":[{"given":"John G.","family":"Webb","sequence":"first","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wood","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Gurvitch","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Bernard","family":"Masson","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rode\u0301s-Cabau","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Osten","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Horlick","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Wendler","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dumont","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Carere","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namal","family":"Wijesinghe","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Nietlispach","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Johnson","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrisopher R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Moss","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Leipsic","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Munt","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel V.","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anson","family":"Cheung","sequence":"additional","affiliation":[{"name":"From St Paul\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., D.A.W., J.Y., R.G., J.-B.M., R.G.C., N.W., F.N., M.J., C.R.T., R.M., J.L., B.M., S.V.L., A.C.); Quebec Heart and Lung Institute, Quebec City, Quebec, Canada (J.R.-C., E.D.); Toronto General Hospital, Toronto, Ontario, Canada (M.O., E.H.); and King\u2019s College Hospital, London, UK (O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116470"},{"key":"e_1_3_2_2_2","first-page":"256","volume":"18","year":"2009","unstructured":"Jaussaud NGV, Giorgi R, Grisoli D, Chalvignac V, Thuny F, Riberi A, Collart F. 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