{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:59:02Z","timestamp":1787990342932,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,6,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC\/AHA Guidelines (CRUSADE) model provides a risk score that predicts the likelihood of major bleeding in patients hospitalized for non\u2013ST-elevation acute myocardial infarction. The aim of the present work was to evaluate the performance of this model in a contemporary cohort of patients hospitalized for non\u2013ST-elevation acute myocardial infarction in Spain.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The study subjects were 782 consecutive patients admitted to our center between February 2004 and June 2009 with non\u2013ST-elevation acute myocardial infarction. For each patient, we calculated the CRUSADE risk score and evaluated its discrimination and calibration by the C statistic and the Hosmer-Lemeshow goodness-of-fit test, respectively. The performance of the CRUSADE risk score was evaluated for the patient population as a whole and for groups of patients treated with or without \u22652 antithrombotic medications and who underwent cardiac catheterization or not. The median CRUSADE score was 30 points (range, 18 to 45). A total of 657 patients (84%) were treated with \u22652 antithrombotic, of whom 609 (92.7%) underwent cardiac catheterization. The overall incidence of major bleeding was 9.5%. This incidence increased with the risk category: very low, 1.5%; low, 4.3%; moderate, 7.8%; high, 11.8%; and very high, 28.9% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). For the patients as a whole, for the groups treated with or without \u22652 antithrombotics, and for the subgroup treated with \u22652 antithrombotics who did or did not undergo cardiac catheterization, the CRUSADE score showed adequate calibration and excellent discriminatory capacity (Hosmer-Lemeshow\n            <jats:italic>P<\/jats:italic>\n            &gt;0.3 and C values of 0.82, 0.80, 0.70, and 0.80, respectively). However, it showed little capacity to discriminate bleeding risk in patients treated with \u22652 antithrombotics who did not undergo cardiac catheterization (C=0.56).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The CRUSADE risk score was generally validated and found to be useful in a Spanish cohort of patients treated with or without \u22652 antithrombotics and in those treated with or without \u22652 antithrombotics who underwent cardiac catheterization. More studies are needed to clarify the validity of the CRUSADE score in the subgroup treated with \u22652 antithrombotics who do not undergo cardiac catheterization.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.109.925594","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T02:29:24Z","timestamp":1274754564000},"page":"2419-2426","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Evaluating the Performance of the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC\/AHA Guidelines (CRUSADE) Bleeding Score in a Contemporary Spanish Cohort of Patients With Non\u2013ST-Segment Elevation Acute Myocardial Infarction"],"prefix":"10.1161","volume":"121","author":[{"given":"Emad","family":"Abu-Assi","sequence":"first","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology Department, Vall d\u2019Hebron Hospital, Barcelona, and Centro de Investigacio\u0301n Biome\u0301dica en Red de Epidemiologi\u0301a y Salud Pu\u0301blica, Spain (I.F.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 Mari\u0301a","family":"Graci\u0301a-Acun\u0303a","sequence":"additional","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology Department, Vall d\u2019Hebron Hospital, Barcelona, and Centro de Investigacio\u0301n Biome\u0301dica en Red de Epidemiologi\u0301a y Salud Pu\u0301blica, Spain (I.F.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ferreira-Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology Department, Vall d\u2019Hebron Hospital, Barcelona, and Centro de Investigacio\u0301n Biome\u0301dica en Red de Epidemiologi\u0301a y Salud Pu\u0301blica, Spain (I.F.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pen\u0303a-Gil","sequence":"additional","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology Department, Vall d\u2019Hebron Hospital, Barcelona, and Centro de Investigacio\u0301n Biome\u0301dica en Red de Epidemiologi\u0301a y Salud Pu\u0301blica, Spain (I.F.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Gayoso-Diz","sequence":"additional","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology Department, Vall d\u2019Hebron Hospital, Barcelona, and Centro de Investigacio\u0301n Biome\u0301dica en Red de Epidemiologi\u0301a y Salud Pu\u0301blica, Spain (I.F.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 Ramo\u0301n","family":"Gonza\u0301lez-Juanatey","sequence":"additional","affiliation":[{"name":"From the Cardiology Department (E.A.A., J.M.G.-A., C.P.-G., J.R.G.-J.) and Clinical Epidemiology and Biostatistics Unit (P.G.-D.), University Hospital, Santiago de Compostela, and Epidemiology Unit, Cardiology 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