{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:48:04Z","timestamp":1787748484054,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,3,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Permanent pacemaker (PPM) requirement is a recognized complication of transcatheter aortic valve implantation. We assessed the UK incidence of permanent pacing within 30 days of CoreValve implantation and formulated an anatomic and electrophysiological model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Data from 270 patients at 10 centers in the United Kingdom were examined. Twenty-five patients (8%) had preexisting PPMs; 2 patients had incomplete data. The remaining 243 were 81.3\u00b16.7 years of age; 50.6% were male. QRS duration increased from 105\u00b123 to 135\u00b129 milliseconds (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Left bundle-branch block incidence was 13% at baseline and 61% after the procedure (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Eighty-one patients (33.3%) required a PPM within 30 days. Rates of pacing according to preexisting ECG abnormalities were as follows: right bundle-branch block, 65.2%; left bundle-branch block, 43.75%; normal QRS, 27.6%. Among patients who required PPM implantation, the median time to insertion was 4.0 days (interquartile range, 2.0 to 7.75 days). Multivariable analysis revealed that periprocedural atrioventricular block (odds ratio, 6.29; 95% confidence interval, 3.55 to 11.15), balloon predilatation (odds ratio, 2.68; 95% confidence interval, 2.00 to 3.47), use of the larger (29 mm) CoreValve prosthesis (odds ratio, 2.50; 95% confidence interval, 1.22 to 5.11), interventricular septum diameter (odds ratio, 1.18; 95% confidence interval, 1.10 to 3.06), and prolonged QRS duration (odds ratio, 3.45; 95% confidence interval, 1.61 to 7.40) were independently associated with the need for PPM.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>One third of patients undergoing a CoreValve transcatheter aortic valve implantation procedure require a PPM within 30 days. Periprocedural atrioventricular block, balloon predilatation, use of the larger CoreValve prosthesis, increased interventricular septum diameter and prolonged QRS duration were associated with the need for PPM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.109.927152","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T03:50:16Z","timestamp":1298346616000},"page":"951-960","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":264,"title":["Permanent Pacemaker Insertion After CoreValve Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"123","author":[{"given":"M.Z.","family":"Khawaja","sequence":"first","affiliation":[{"name":"From the UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton &amp; Sussex University Hospital Trust, Brighton, East Sussex, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rajani","sequence":"additional","affiliation":[{"name":"From the UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton &amp; 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