{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:45:56Z","timestamp":1773326756497,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,5,31]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>We have noted abnormal angiographic findings\u2014at the sites of drug-eluting stent implantation, suggesting contrast staining outside the stent struts\u2014that do not fulfill the classic definition of coronary artery aneurysm. We propose a new term, peri-stent contrast staining (PSS), for these abnormal angiographic findings and assess their incidence, risk factors, and clinical sequelae.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Peri-stent contrast staining was defined as contrast staining outside the stent contour extending to \u226520% of the stent diameter. The study population consisted of 3081 lesions (1998 patients) that were treated exclusively with sirolimus-eluting stents and were evaluated by follow-up angiography within 12 months after sirolimus-eluting stent implantation in a single center. Late acquired PSS was observed in 58 lesions (1.9%) in 49 patients (2.5%). Independent risk factors of PSS included chronic total occlusion, whereas negative risk factors for PSS were left circumflex coronary artery lesion and in-stent restenosis lesion. Stent fracture was more frequently observed in lesions with PSS than in lesions without PSS (43.1% versus 5.4%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Excluding 269 lesions with target-lesion revascularization within 12 months, the study population for long-term follow-up consisted of 51 lesions (42 patients) with PSS and 2761 lesions (1751 patients) without PSS. Cumulative incidence of target-lesion revascularization and definite very late stent thrombosis at 3 years in the PSS group was higher than that in the non-PSS group (15.0% versus 6.5%, and 8.2% versus 0.2%, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Peri-stent contrast staining found within 12 months after sirolimus-eluting stent implantation appeared to be associated with subsequent target-lesion revascularization and very late stent thrombosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.110.003459","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T05:12:11Z","timestamp":1305609131000},"page":"2382-2391","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Incidence, Risk Factors, and Clinical Sequelae of Angiographic Peri-Stent Contrast Staining After Sirolimus-Eluting Stent Implantation"],"prefix":"10.1161","volume":"123","author":[{"given":"Masao","family":"Imai","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Goto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoki","family":"Fujii","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Fuku","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Hosogi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Hirono","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Tada","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. 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Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. Kozuma, N..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Inoue","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M.I., H.S., T.K.); Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan (K. Kadota, T.G., S.F., H.Y., Y.F., S.H., A.H., H.T., T.T., K.M.); Center for Medical Education and Clinical Epidemiology Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan (T.M.); Department of Cardiovascular Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan (K. 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