{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:14:18Z","timestamp":1783491258122,"version":"3.55.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,5,31]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 1914 consecutive patients with multivessel coronary disease undergoing drug-eluting stent implantation (1400 patients) or coronary artery bypass graft surgery (514 patients) were enrolled. Angiographic CR was defined as revascularization in all diseased segments according to the Synergy Between PCI With Taxus and Cardiac Surgery classification. The outcomes of patients undergoing CR were compared with those undergoing incomplete revascularization (IR) after adjustments with the inverse-probability-of-treatment weighting method. Angiographic CR was performed in 917 patients (47.9%) including 573 percutaneous coronary intervention (40.9%) and 344 coronary artery bypass graft (66.9%) patients. CR patients were younger and had more extensive coronary disease than IR patients. Over 5 years, CR patients had comparable incidences of death (8.9% versus 8.9%; adjusted hazard ratio, 1.04; 95% confidence interval, 0.76 to 1.43;\n              <jats:italic>P<\/jats:italic>\n              =0.81), the composite of death, myocardial infarction, and stroke (12.1% versus 11.9%; adjusted hazard ratio, 1.04; 95% confidence interval, 0.79 to 1.36;\n              <jats:italic>P<\/jats:italic>\n              =0.80), and the composite of death, myocardial infarction, stroke, and repeat revascularization (22.4% versus 24.9%; adjusted hazard ratio, 0.91; 95% confidence interval, 0.75 to 1.10;\n              <jats:italic>P<\/jats:italic>\n              =0.32) compared with IR patients. However, 368 patients (19.2%) with multivessel IR had a greater tendency toward higher risk of death, myocardial infarction, stroke, or repeat revascularization (30.3% versus 22.1%; adjusted hazard ratio, 1.27; 95% confidence interval, 0.97 to 1.66;\n              <jats:italic>P<\/jats:italic>\n              =0.079) than those without multivessel IR.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Angiographic CR with drug-eluting stent implantation or coronary artery bypass grafting did not improve long-term clinical outcomes in patients with multivessel disease. This finding supports the strategy of ischemia-guided revascularization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.110.005041","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T05:12:11Z","timestamp":1305609131000},"page":"2373-2381","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["Impact of Angiographic Complete Revascularization After Drug-Eluting Stent Implantation or Coronary Artery Bypass Graft Surgery for Multivessel Coronary Artery Disease"],"prefix":"10.1161","volume":"123","author":[{"given":"Young-Hak","family":"Kim","sequence":"first","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Jang","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Cheol","family":"Yun","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Geun","family":"Song","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hyok","family":"Oh","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seon","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiac Institute (Y.K., D.P., J.L., W.K., J.A., H.G.S., J.O., J.S.P., S.K., S.L., C.W.L., S.-W.P., S.-J.P.) and Division of Biostatistics (S.Y.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.612267"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.08.021"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902905"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.750109"},{"key":"e_1_3_3_6_2","first-page":"e166","article-title":"ACC\/AHA\/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (ACC\/AHA\/SCAI Writing Committee to Update 2001 Guidelines for Percutaneous Coronary Intervention)","volume":"113","author":"Smith SC","year":"2006","unstructured":"Smith SC, Feldman TE, Hirshfeld JW, Jacobs AK, Kern MJ, King SB, Morrison DA, O'Neill WW, Schaff HV, Whitlow PL, Williams DO, Antman EM, Adams CD, Anderson JL, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Nishimura R, Ornato JP, Page RL, Riegel B. ACC\/AHA\/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (ACC\/AHA\/SCAI Writing Committee to Update 2001 Guidelines for Percutaneous Coronary Intervention). Circulation. 2006;113:e166\u2013e286.","journal-title":"Circulation"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138790.14877.7D"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.12.004"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071804"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_11_2","first-page":"219","article-title":"The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease","volume":"1","author":"Sianos AMM","year":"2005","unstructured":"Sianos AMM, Kappentein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Dyck NV, Russell ME, Mohr FW, Serruys PW. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1:219\u2013227.","journal-title":"EuroIntervention"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01806-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.844316"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01785-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531402"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00011"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.800805"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.10.035"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.01.011"},{"key":"e_1_3_3_20_2","first-page":"102","article-title":"Percutaneous coronary interventions in diabetic patients: is complete revascularization important?","volume":"16","author":"Nikolsky E","year":"2004","unstructured":"Nikolsky E, Gruberg L, Patil CV, Roguin A, Kapeliovich M, Petcherski S, Boulos M, Grenadier E, Amikam S, Linn S, Markiewicz W, Beyar R. 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