{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:18:35Z","timestamp":1791566315713,"version":"4.3.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,10,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>We hypothesized that combined assessment of factors that are associated with favorable reverse remodeling after cardiac resynchronization-defibrillator therapy (CRT-D) can be used to predict clinical response to the device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      The study population comprised 1761 patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT). Best-subset regression analysis was performed to identify factors associated with echocardiographic response (defined as percent reduction in left ventricular end-diastolic volume 1 year after CRT-D implantation) and to create a response score. Cox proportional hazards regression analysis was used to evaluate the CRT-D versus defibrillator-only reduction in the risk of heart failure or death by the response score. Seven factors were identified as associated with echocardiographic response to CRT-D and made up the response score (female sex, nonischemic origin, left bundle-branch block, QRS \u2265150 milliseconds, prior hospitalization for heart failure, left ventricular end-diastolic volume \u2265125 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and left atrial volume &lt;40 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Multivariate analysis showed a 13% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) increase in the clinical benefit of CRT-D per 1-point increment in the response score (range, 0\u201314) and a significant direct correlation between risk reduction associated with CRT-D and response score quartiles: Patients in the first quartile did not derive a significant reduction in the risk of heart failure or death with CRT-D (hazard ratio=0.87;\n                      <jats:italic>P<\/jats:italic>\n                      =0.52); patients in the second and third quartiles derived 33% (\n                      <jats:italic>P<\/jats:italic>\n                      =0.04) and 36% (\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) risk reductions, respectively; and patients in the upper quartile experienced a 69% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) risk reduction (\n                      <jats:italic>P<\/jats:italic>\n                      for trend=0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2014<\/jats:title>\n                    <jats:p>Combined assessment of factors associated with reverse remodeling can be used for improved selection of patients for cardiac resynchronization therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00180271.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.110.014324","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:17:56Z","timestamp":1315354676000},"page":"1527-1536","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":288,"title":["Predictors of Response to Cardiac Resynchronization Therapy in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT)"],"prefix":"10.1161","volume":"124","author":[{"given":"Ilan","family":"Goldenberg","sequence":"first","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J.","family":"Moss","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jackson","family":"Hall","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse","family":"Foster","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Goldberger","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Santucci","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Shinn","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Solomon","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilber","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Barsheshet","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Heart Research Follow-Up Program (I.G., A.J.M., W.J.H., S.M., A.B., W.Z., H.K.) and Department of Biostatistics (W.J.H.), University of Rochester Medical Center, Rochester, NY; University of California Medical Center, San Francisco (E.F.); Northwestern University Feinberg School of Medicine, Chicago, IL (J.J.G.); Loyola University Medical Center, Maywood, IL (D.W., P.S.); Michigan Heart PC, Ypsilanti (T.S.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.D.S.); and St...."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl099"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.6.730"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000146336.92331.d1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.011"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2685"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01012-1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2001.25652"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.955039"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.538272"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.032"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circualtionaha.108.189742"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.960898"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi662"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-5-200409070-00102"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.520817"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.022"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00870.x"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065226.24159.E9"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.08.069"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.009"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.000646"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.009"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.10.015"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.894774"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh101"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706695"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.110.014324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:05:14Z","timestamp":1715565914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.110.014324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,4]]},"references-count":33,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2011,10,4]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.110.014324"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.110.014324","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,4]]},"assertion":[{"value":"2010-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}