{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:16:57Z","timestamp":1793765817563,"version":"4.6.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,11,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Because traditional nonsteroidal antiinflammatory drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on the assumption of its greater cardiovascular safety. Data from randomized clinical trials prospectively addressing cardiovascular safety of acetaminophen, however, are still lacking, particularly in patients at increased cardiovascular risk. Hence, the aim of this study was to evaluate the safety of acetaminophen in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      The 33 patients with coronary artery disease included in this randomized, double-blind, placebo-controlled, crossover study received acetaminophen (1 g TID) on top of standard cardiovascular therapy for 2 weeks. Ambulatory blood pressure, heart rate, endothelium-dependent and -independent vasodilatation, platelet function, endothelial progenitor cells, markers of the renin-angiotensin system, inflammation, and oxidative stress were determined at baseline and after each treatment period. Treatment with acetaminophen resulted in a significant increase in mean systolic (from 122.4\u00b111.9 to 125.3\u00b112.0 mm Hg\n                      <jats:italic>P<\/jats:italic>\n                      =0.02 versus placebo) and diastolic (from 73.2\u00b16.9 to 75.4\u00b17.9 mm Hg\n                      <jats:italic>P<\/jats:italic>\n                      =0.02 versus placebo) ambulatory blood pressures. On the other hand, heart rate, endothelial function, early endothelial progenitor cells, and platelet function did not change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>This study demonstrates for the first time that acetaminophen induces a significant increase in ambulatory blood pressure in patients with coronary artery disease. Thus, the use of acetaminophen should be evaluated as rigorously as traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors, particularly in patients at increased cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00534651.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.110.956490","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T22:04:18Z","timestamp":1287439458000},"page":"1789-1796","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":148,"title":["Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease"],"prefix":"10.1161","volume":"122","author":[{"given":"Isabella","family":"Sudano","sequence":"first","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"P\u00e9riat","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Enseleit","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hermann","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Wolfrum","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Hirt","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priska","family":"Kaiser","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hurlimann","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Neidhart","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Gay","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Holzmeister","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; Department of Internal Medicine, Division of Angiology and Hypertension, University Hospital Lausanne, Lausanne, Switzerland (J.N.); Institute for Social and Preventive Medicine, Biostatistics Unit (S.R.H.) and Center..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juerg","family":"Nussberger","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Cardiology (I.S., A.J.F., D.P., F.E., M.H., M.W., A.H., P.K., D.H., J.H., U.L., R.C., T.F.L., G.N., F.R.), Department of Rheumatology (M.N.), and Cardiovascular Research, Institute of Physiology (P.M.), University Hospital Zurich, Zurich, Switzerland; 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