{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:27:09Z","timestamp":1780385229665,"version":"3.54.1"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,6,21]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The widely reported inverse association between birth weight and risk of cardiovascular disease (CVD) has sparked theories about early life determinants of adult disease. Within-twin-pair analysis provides a unique opportunity to investigate whether factors shared within twin pairs influence the association.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>In a population-based cohort of like-sexed twins with known zygosity born in Sweden from 1926 to 1958, disease-discordant twin pairs were identified through linkage to the National Inpatient and Cause of Death registers between 1973 and 2006. Co-twin\u2013control analyses were performed on twins discordant for cardiovascular disease (n=3884), coronary heart disease (n=2668), and stroke (n=1372). Overall, inverse associations between birth weight and risk of cardiovascular diseases were seen within dizygotic but not monozygotic twin pairs. In dizygotic twins, the odds ratios for a 1-kg within-pair increase in birth weight were 0.74 (95% confidence interval, 0.56 to 0.98) for coronary heart disease and 0.57 (95% confidence interval, 0.37 to 0.88) for stroke. Conversely, no statistically significant associations were found within monozygotic twins (for coronary heart disease: odds ratio, 1.10; 95% confidence interval, 0.73 to 1.68; for stroke: odds ratio, 0.92; 95% confidence interval, 0.48 to 1.80).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>We found an association between birth weight and risk of cardiovascular disease within disease-discordant dizygotic but not monozygotic twin pairs. This indicates that the association between birth weight and cardiovascular disease could be a result of common causes, and that factors that vary within dizygotic but not monozygotic twin pairs may help identify them.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.110.987339","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T04:35:51Z","timestamp":1306902951000},"page":"2792-2798","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs"],"prefix":"10.1161","volume":"123","author":[{"given":"Sara","family":"\u00d6berg","sequence":"first","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (S.\u00d6., S.S., P.L., A.N.I.), and Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital (S.C.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cnattingius","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (S.\u00d6., S.S., P.L., A.N.I.), and Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital (S.C.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Sandin","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (S.\u00d6., S.S., P.L., A.N.I.), and Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital (S.C.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (S.\u00d6., S.S., P.L., A.N.I.), and Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital (S.C.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia N.","family":"Iliadou","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (S.\u00d6., S.S., P.L., A.N.I.), and Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital (S.C.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1244"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04257-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7105.396"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6918.1519"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq2672011"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018070-00002"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.886"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000135998.08025.FB"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.617ad.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.019"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31818131b9"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.674812"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05111-4"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01032.x"},{"key":"e_1_3_4_17_2","first-page":"338","article-title":"Studies on similarity diagnosis in twins with the aid of mailed questionnaires","volume":"11","author":"Cederlof R","year":"1961","unstructured":"Cederlof R, Friberg L, Jonsson E, Kaij L. 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