{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:37:33Z","timestamp":1787503053768,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,9,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Transluminal balloon tearing of the membrane in a thin discrete subaortic stenosis is an alternative to membrane surgical resection. However, the long-term outcome of patients with isolated thin discrete subaortic stenosis treated by transluminal balloon tearing remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      This 25-year study describes findings from 76 patients with isolated thin discrete subaortic stenosis who underwent percutaneous transluminal balloon tearing of the membrane and were followed up for a mean period of 16\u00b16 years. The age at presentation had a wide range (2\u201367 years). The mean age at treatment was 19\u00b116 years. Immediately after treatment, the subvalvular gradient decreased from 70\u00b127 to 18\u00b112 mm Hg (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). No significant postprocedural aortic regurgitation was observed. After a mean follow-up time of 16\u00b16 years, 11 patients (15%) developed restenosis, 3 patients (4%) progressed to muscular obstructive disease, and 1 patient (1.3%) developed a new distant obstructive membrane. Twelve patients (16%) were redilated at a mean of 5\u00b13 years after their first treatment, and 4 patients (5%) underwent surgery at a mean of 3\u00b12 years after their first treatment. Fifty-eight patients (77%) remained alive and free of redilation or surgery at follow-up. Larger annulus diameter and thinner membranes were independent factors associated with better long-term results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Most patients (77%) with isolated thin discrete subaortic stenosis treated with transluminal balloon tearing of the membrane had sustained relief at subsequent follow-ups without restenosis, the need for surgery, progression to muscular obstructive disease, or an increase in the degree of aortic regurgitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.111.019448","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T20:36:17Z","timestamp":1314650177000},"page":"1461-1468","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Long-Term Outcome of Patients With 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Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (Jos\u00e9 S.d.L.) and Department of Cardiology, University Hospital \u201cReina Sof\u00eda,\u201d (M.R., J.S., M.P., Javier S.d.L., D.P., F.M., M.D., D.M.), C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djordje","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"From the Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (Jos\u00e9 S.d.L.) and Department of Cardiology, University Hospital \u201cReina Sof\u00eda,\u201d (M.R., J.S., M.P., Javier S.d.L., D.P., F.M., M.D., D.M.), C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mazuelos","sequence":"additional","affiliation":[{"name":"From the Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (Jos\u00e9 S.d.L.) and Department of Cardiology, University Hospital \u201cReina Sof\u00eda,\u201d (M.R., J.S., 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