{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:42:17Z","timestamp":1790055737547,"version":"4.0.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Up to 5% of the population may have a brain aneurysm. If the brain aneurysm ruptures, there is &gt;50% mortality, and more than one third of survivors are dependent. Brain aneurysms detected before rupture can be treated to prevent rupture, or ruptured aneurysms can be treated to prevent rerupture. Endovascular coiling of brain aneurysms is the treatment of choice for some aneurysms; however, up to one quarter of aneurysms may recur. The coiled aneurysms that do not recur are characterized by inflammatory intra-aneurysmal tissue healing; therefore, we studied the biology of this process, specifically the role of monocyte chemotactic protein-1 (MCP-1), a cytokine known for tissue healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      We created coils with a 50:50 poly-\n                      <jats:sc>dl<\/jats:sc>\n                      -lactic glycolic acid (PLGA) coating that released MCP-1 at 3 different doses (100 \u03bcg\/mL, 1 mg\/mL, and 10 mg\/mL) and performed a dose-response study for effect on intra-aneurysmal tissue healing in a murine carotid aneurysm model. We then demonstrated that MCP-1 (100 \u03bcg\/mL)\u2013releasing coils promote significantly greater aneurysm tissue in-growth than bare platinum or PLGA-only coils. We show that MCP-1 recruits the migration of fibroblasts, macrophages, smooth muscle cells, and endothelial cells in vitro in cell migration assays and in vivo in murine carotid aneurysms. Using\n                      <jats:italic>gfp<\/jats:italic>\n                      <jats:sup>+<\/jats:sup>\n                      bone marrow-transplant chimeric mice, we demonstrate that the MCP-1\u2013recruited fibroblasts and macrophages are derived from the bone marrow. We demonstrate that this MCP-1\u2013mediated vascular inflammatory repair occurs via a macrophage inflammatory protein (MIP)-1\u03b1\u2013 and MIP-2\u2013dependent pathway. MCP-1 released from coiled murine aneurysms causes significant upregulation of MIP-1\u03b1 and MIP-2 expression by cytokine array assay. Blocking MIP-1\u03b1 and MIP-2 with antagonist antibody causes a significant decrease in MCP-1\u2013mediated intra-aneurysmal tissue healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u2014<\/jats:title>\n                    <jats:p>Our findings suggest that MCP-1 has a critical role in promoting inflammatory intra-aneurysmal tissue healing in an MIP-1\u03b1\u2013 and MIP-2\u2013dependent pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.111.036061","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T01:50:26Z","timestamp":1318902626000},"page":"2243-2252","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Monocyte Chemotactic Protein-1 Promotes Inflammatory Vascular Repair of Murine Carotid Aneurysms via a Macrophage Inflammatory Protein-1\u03b1 and Macrophage Inflammatory Protein-2\u2013Dependent Pathway"],"prefix":"10.1161","volume":"124","author":[{"given":"Brian L.","family":"Hoh","sequence":"first","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hosaka","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Downes","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil W.","family":"Nowicki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina E.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Batich","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Scott","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (B.L.H., K.H., D.P.D.), Materials Science and Engineering (C.E.F., C.D.B.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida (K.W.N.), 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