{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:43:07Z","timestamp":1789789387641,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2011,11,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Low-density lipoprotein (LDL) that contains apolipoprotein (apo) C-III makes up only 10% to 20% of plasma LDL but has a markedly altered metabolism and proatherogenic effects on vascular cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We examined the association between plasma LDL with apoC-III and coronary heart disease in 320 women and 419 men initially free of cardiovascular disease who developed a fatal or nonfatal myocardial infarction during 10 to 14 years of follow-up and matched controls who remained free of coronary heart disease. Concentrations of LDL with apoC-III (measured as apoB in this fraction) were associated with risk of coronary heart disease in multivariable analysis that included the ratio of total cholesterol to high-density lipoprotein cholesterol, LDL cholesterol, apoB, triglycerides, or high-density lipoprotein cholesterol and other risk factors. In all models, the relative risks for the top versus bottom quintile of LDL with apoC-III were greater than those for LDL without apoC-III. When included in the same multivariable-adjusted model, the risk associated with LDL with apoC-III (relative risk for top versus bottom quintile, 2.38; 95% confidence interval, 1.54\u20133.68;\n              <jats:italic>P<\/jats:italic>\n              for trend &lt;0.001) was significantly greater than that associated with LDL without apoC-III (relative risk for top versus bottom quintile, 1.25; 95% confidence interval, 0.76\u20132.05;\n              <jats:italic>P<\/jats:italic>\n              for trend=0.97;\n              <jats:italic>P<\/jats:italic>\n              for interaction &lt;0.001). This divergence in association with coronary heart disease persisted even after adjustment for plasma triglycerides.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The risk of coronary heart disease contributed by LDL appeared to result to a large extent from LDL that contains apoC-III.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.111.056986","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T05:29:30Z","timestamp":1318310970000},"page":"2065-2072","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":126,"title":["Low-Density Lipoproteins Containing Apolipoprotein C-III and the Risk of Coronary Heart Disease"],"prefix":"10.1161","volume":"124","author":[{"given":"Carlos O.","family":"Mendivil","sequence":"first","affiliation":[{"name":"From the Harvard School of Public Health, Boston, MA (C.O.M., E.B.R., J.F., S.E.C., F.M.S.); Universidad de los Andes Medical School, Bogot\u00e1, Colombia (C.O.M.); and Channing Laboratory (E.B.R., F.M.S.) and Division of Preventive Medicine, Department of Medicine (E.B.R., S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Rimm","sequence":"additional","affiliation":[{"name":"From the Harvard School of Public Health, Boston, MA (C.O.M., E.B.R., J.F., S.E.C., F.M.S.); Universidad de los Andes Medical School, Bogot\u00e1, Colombia (C.O.M.); and Channing Laboratory (E.B.R., F.M.S.) and Division of Preventive Medicine, Department of Medicine (E.B.R., S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Furtado","sequence":"additional","affiliation":[{"name":"From the Harvard School of Public Health, Boston, MA (C.O.M., E.B.R., J.F., S.E.C., F.M.S.); Universidad de los Andes Medical School, Bogot\u00e1, Colombia (C.O.M.); and Channing Laboratory (E.B.R., F.M.S.) and Division of Preventive Medicine, Department of Medicine (E.B.R., S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Chiuve","sequence":"additional","affiliation":[{"name":"From the Harvard School of Public Health, Boston, MA (C.O.M., E.B.R., J.F., S.E.C., F.M.S.); Universidad de los Andes Medical School, Bogot\u00e1, Colombia (C.O.M.); and Channing Laboratory (E.B.R., F.M.S.) and Division of Preventive Medicine, Department of Medicine (E.B.R., S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Sacks","sequence":"additional","affiliation":[{"name":"From the Harvard School of Public Health, Boston, MA (C.O.M., E.B.R., J.F., S.E.C., F.M.S.); Universidad de los Andes Medical School, Bogot\u00e1, Colombia (C.O.M.); and Channing Laboratory (E.B.R., F.M.S.) and Division of Preventive Medicine, Department of Medicine (E.B.R., S.E.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)63004-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)31574-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000066131.01313.EB"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070308"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P600011-JLR200"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.197830"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E607"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55263-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.875807"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.622514"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.591743"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.784785"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0206"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.470"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.42"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37594-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.16.1886"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116211"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1997.6.49"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115960"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199601000-00014"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/65.1.153"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33358-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(94)00171-T"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.178426"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000249620.68705.0d"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161524"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.4.715"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00524-1"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D300041-JLR200"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1837"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0302.102575"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.6.611"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.111.056986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:53:40Z","timestamp":1715579620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.111.056986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":33,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2011,11,8]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.111.056986"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.111.056986","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,8]]},"assertion":[{"value":"2011-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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