{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:22:07Z","timestamp":1790036527099,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2012,3,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring &gt;1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents (EES).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We assessed the risk of stent thrombosis in a cohort of 12 339 patients with unrestricted use of drug-eluting stents (3819 SES, 4308 PES, 4212 EES). Results are incidence rates per 100 person-years after inverse probability of treatment weighting to adjust for group differences. During follow-up of up to 4 years, the overall incidence rate of definite stent thrombosis was lower with EES (1.4 per 100 person-years) compared with SES (2.9; hazard ratio, 0.41; 95% confidence interval, 0.27\u20130.62;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and PES (4.4; hazard ratio, 0.33; 95% confidence interval, 0.23\u20130.48;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). The incidence rate per 100 person-years of early (0\u201330 days), late (31 days\u20131 year), and very late stent thrombosis amounted to 0.6, 0.1, and 0.6 among EES-treated patients; 1.0, 0.3, and 1.6 among SES-treated patients; and 1.3, 0.7, and 2.4 among PES-treated patients. Differences in favor of EES were most pronounced beyond 1 year, with a hazard ratio of 0.33 (EES versus SES;\n              <jats:italic>P<\/jats:italic>\n              =0.006) and 0.34 (EES versus PES;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). There was a lower risk of cardiac death or myocardial with EES compared with PES (hazard ratio, 0.65; 95% confidence interval, 0.56\u20130.75;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), which was directly related to the lower risk of stent thrombosis\u2013associated events (EES versus PES: hazard ratio, 0.36; 95% confidence interval, 0.23\u20130.57).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Current treatment with EES is associated with a lower risk of very late stent thrombosis compared with early-generation drug-eluting stents.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.111.058560","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T20:29:58Z","timestamp":1328214598000},"page":"1110-1121","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":347,"title":["Very Late Coronary Stent Thrombosis of a Newer-Generation Everolimus-Eluting Stent Compared With Early-Generation Drug-Eluting Stents"],"prefix":"10.1161","volume":"125","author":[{"given":"Lorenz","family":"R\u00e4ber","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Magro","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio G.","family":"Stefanini","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Kalesan","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"van Domburg","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wenaweser","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Meier","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (L.R., G.G.S., P.W., B.M., S.W.); Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.R., M.M., R.T.v.D., Y.O., J.D., P.W.S.); and Institute of Social and Preventive Medicine (B.K., P.J.) and Clinical Trials Unit Bern, Department of Clinical Research (P.J., S.W.), University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.799403"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.903955"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067484"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067193"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61444-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.762047"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.658237"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.854398"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn553"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.066"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.08.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62127-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910496"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009406"},{"key":"e_1_3_3_18_2","volume-title":"Paper presented at: Transcatheter Cardiovascular Therapeutics Congress","author":"Okkels Jensen L","unstructured":"Okkels Jensen L. 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