{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:17:13Z","timestamp":1777544233119,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2012,1,31]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The present study was designed to investigate the long-term prognostic impact of procedure-related and spontaneous myocardial infarction (MI) on cardiovascular mortality in patients with non\u2013ST-elevation acute coronary syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Five-year follow-up after procedure-related or spontaneous MI was investigated in the individual patient pooled data set of the FRISC-II (Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Randomized Intervention Trial of Unstable Angina 3) non\u2013ST-elevation acute coronary syndrome trials. The principal outcome was cardiovascular death up to 5 years of follow-up. Cumulative event rates were estimated by the Kaplan-Meier method; hazard ratios were calculated with time-dependent Cox proportional hazards models. Adjustments were made for the variables associated with long-term outcomes. Among the 5467 patients, 212 experienced a procedure-related MI within 6 months after enrollment. A spontaneous MI occurred in 236 patients within 6 months. The cumulative cardiovascular death rate was 5.2% in patients who had a procedure-related MI, comparable to that for patients without a procedure-related MI (hazard ratio 0.66; 95% confidence interval, 0.36\u20131.20,\n              <jats:italic>P<\/jats:italic>\n              =0.17). In patients who had a spontaneous MI within 6 months, the cumulative cardiovascular death rate was 22.2%, higher than for patients without a spontaneous MI (hazard ratio 4.52; 95% confidence interval, 3.37\u20136.06,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). These hazard ratios did not change materially after risk adjustments.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Five-year follow-up of patients with non\u2013ST-elevation acute coronary syndrome from the 3 trials showed no association between a procedure-related MI and long-term cardiovascular mortality. In contrast, there was a substantial increase in long-term mortality after a spontaneous MI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.controlled-trials.com\/ISRCTN82153174\">http:\/\/www.controlled-trials.com\/ISRCTN82153174<\/jats:ext-link>\n              (ICTUS);\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.controlled-trials.com\/ISRCTN07752711\">http:\/\/www.controlled-trials.com\/ISRCTN07752711<\/jats:ext-link>\n              (RITA-3).\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.111.061663","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T01:41:59Z","timestamp":1324690919000},"page":"568-576","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":89,"title":["Long-Term Cardiovascular Mortality After Procedure-Related or Spontaneous Myocardial Infarction in Patients With Non\u2013ST-Segment Elevation Acute Coronary Syndrome"],"prefix":"10.1161","volume":"125","author":[{"given":"Peter","family":"Damman","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.A.","family":"Fox","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fons","family":"Windhausen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hirsch","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Clayton","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Pocock","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lagerqvist","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.P.","family":"Tijssen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robbert J.","family":"de Winter","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Netherlands (P.D., F.W., A.H., J.G.P.T., R.J.W.); Department of Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (P.D., L.W., B.L.); Centre for Cardiovascular Science, Royal Infirmary, Edinburgh, United Kingdom (K.A.A.F.); and London School of Hygiene and Tropical Medicine, London, United Kingdom (T.C., S.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550060055036"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01290-6"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)01044-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.483297"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.478347"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05060-1"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2736"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.063"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02427-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09894-X"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044259"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.007"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69416-6"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.026"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67222-4"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90083-6"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540300029029"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02538-X"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000028146.71416.2e"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093902"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02299-8"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00095-4"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912134"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.959080"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.058"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.111.061663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:56:59Z","timestamp":1715579819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.111.061663"}},"subtitle":["A Collaborative Analysis of Individual Patient Data From the FRISC II, ICTUS, and RITA-3 Trials (FIR)"],"short-title":[],"issued":{"date-parts":[[2012,1,31]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,1,31]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.111.061663"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.111.061663","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,31]]},"assertion":[{"value":"2011-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}