{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:58:28Z","timestamp":1791932308015,"version":"4.3.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2012,5]]},"abstract":"\n Background\u2014<\/jats:title>\n Survivors of the Norwood procedure may experience neurodevelopmental impairment. Clinical trials to improve outcomes have focused primarily on methods of vital organ support during cardiopulmonary bypass.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results\u2014<\/jats:title>\n \n In the Single Ventricle Reconstruction trial of the Norwood procedure with modified Blalock-Taussig shunt versus right-ventricle-to-pulmonary-artery shunt, 14-month neurodevelopmental outcome was assessed by use of the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. We used multivariable regression to identify risk factors for adverse outcome. Among 373 transplant-free survivors, 321 (86%) returned at age 14.3\u00b11.1 (mean\u00b1SD) months. Mean PDI (74\u00b119) and MDI (89\u00b118) scores were lower than normative means (each\n P<\/jats:italic>\n <0.001). Neither PDI nor MDI score was associated with type of Norwood shunt. Independent predictors of lower PDI score (\n R<\/jats:italic>\n 2<\/jats:sup>\n =26%) were clinical center (\n P<\/jats:italic>\n =0.003), birth weight <2.5 kg (\n P<\/jats:italic>\n =0.023), longer Norwood hospitalization (\n P<\/jats:italic>\n <0.001), and more complications between Norwood procedure discharge and age 12 months (\n P<\/jats:italic>\n <0.001). Independent risk factors for lower MDI score (\n R<\/jats:italic>\n 2<\/jats:sup>\n =34%) included center (\n P<\/jats:italic>\n <0.001), birth weight <2.5 kg (\n P<\/jats:italic>\n =0.04), genetic syndrome\/anomalies (\n P<\/jats:italic>\n =0.04), lower maternal education (\n P<\/jats:italic>\n =0.04), longer mechanical ventilation after the Norwood procedure (\n P<\/jats:italic>\n <0.001), and more complications after Norwood discharge to age 12 months (\n P<\/jats:italic>\n <0.001). We found no significant relationship of PDI or MDI score to perfusion type, other aspects of vital organ support (eg, hematocrit, pH strategy), or cardiac anatomy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n Neurodevelopmental impairment in Norwood survivors is more highly associated with innate patient factors and overall morbidity in the first year than with intraoperative management strategies. Improved outcomes are likely to require interventions that occur outside the operating room.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration\u2014<\/jats:title>\n \n URL:\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier: NCT00115934.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circulationaha.111.064113","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T23:18:43Z","timestamp":1332976723000},"page":"2081-2091","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":348,"title":["Early Developmental Outcome in Children With Hypoplastic Left Heart Syndrome and Related Anomalies"],"prefix":"10.1161","volume":"125","author":[{"given":"Jane W.","family":"Newburger","sequence":"first","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Sleeper","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Bellinger","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren S.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tabbutt","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Lu","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Mussatto","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismee A.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Mital","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Pike","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Sood","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Mahle","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Dunbar-Masterson","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Dent","family":"Krawczeski","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); New England Research Institutes, Watertown, MA (L.A.S., M.L.); University of Michigan Medical School, Ann Arbor, MI (C.S.G., R.G.O.); Children's Hospital of Philadelphia & University of Pennsylvania Medical School, Philadelphia, PA (S.T., C.R., J.W.G.); Children's Hospital of Wisconsin & Medical College of Wisconsin, Milwaukee, WI (K.A.M.); Morgan Stanley Children's Hospital of New York..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Lewis","sequence":"additional","affiliation":[{"name":"From the Children's Hospital Boston & Harvard Medical School, Boston, MA (J.W.N., D.C.B., C.D.-B.); 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