{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:59:30Z","timestamp":1762505970501},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11_suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2012,9,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The Second Medicine, Angioplasty, or Surgery Study (MASS II) included patients with multivessel coronary artery disease and normal systolic ventricular function. Patients underwent coronary artery bypass graft surgery (CABG, n=203), percutaneous coronary intervention (PCI, n=205), or medical treatment alone (MT, n=203). This investigation compares the economic outcome at 5-year follow-up of the 3 therapeutic strategies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We analyzed cumulative costs during a 5-year follow-up period. To analyze the cost-effectiveness, adjustment was made on the cumulative costs for average event-free time and angina-free proportion. Respectively, for event-free survival and event plus angina-free survival, MT presented 3.79 quality-adjusted life-years and 2.07 quality-adjusted life-years; PCI presented 3.59 and 2.77 quality-adjusted life-years; and CABG demonstrated 4.4 and 2.81 quality-adjusted life-years. The event-free costs were $9071.00 for MT; $19 967.00 for PCI; and $18 263.00 for CABG. The paired comparison of the event-free costs showed that there was a significant difference favoring MT versus PCI (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and versus CABG (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and CABG versus PCI (\n              <jats:italic>P<\/jats:italic>\n              =0.01). The event-free plus angina-free costs were $16 553.00, $25 831.00, and $24 614.00, respectively. The paired comparison of the event-free plus angina-free costs showed that there was a significant difference favoring MT versus PCI (\n              <jats:italic>P<\/jats:italic>\n              =0.04), and versus CABG (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001); there was no difference between CABG and PCI (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In the long-term economic analysis, for the prevention of a composite primary end point, MT was more cost effective than CABG, and CABG was more cost-effective than PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration Information\u2014<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.controlled-trials.com\">www.controlled-trials.com<\/jats:ext-link>\n              . Registration number: ISRCTN66068876.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.111.084442","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T20:34:09Z","timestamp":1347309249000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Cost-Effectiveness Analysis for Surgical, Angioplasty, or Medical Therapeutics for Coronary Artery Disease"],"prefix":"10.1161","volume":"126","author":[{"given":"Ricardo D'Oliveira","family":"Vieira","sequence":"first","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whady","family":"Hueb","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hlatky","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiderio","family":"Favarato","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Cury","family":"Rezende","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cibele Larrosa","family":"Garzillo","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Gomes","family":"Lima","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Rog\u00e9rio","family":"Soares","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Ciappina","family":"Hueb","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Costa","family":"Pereira","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio Franchini","family":"Ramires","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Kalil","family":"Filho","sequence":"additional","affiliation":[{"name":"From the Department of Atherosclerosis, Heart Institute of the University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil (R.D.V., W.H., D.F., P.C.R., C.L.G., E.G.L., P.R.S., A.C.H., A.C.P., J.A.F.R., R.K.F.); and Stanford University School of Medicine, Stanford, CA (M.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60552-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.625475"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.108.798462"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.912709"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92274-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01074-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360203"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104123441502"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90534-V"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2008001800003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000087381.98299.7b"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.065"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.3.947585"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/acc.2.1.41.50"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774506073105"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.018"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1050(200004)9:3<235::AID-HEC502>3.0.CO;2-O"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38737.607558.80"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.3075"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.111.084442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:44:02Z","timestamp":1715582642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.111.084442"}},"subtitle":["5-Year Follow-Up of Medicine, Angioplasty, or Surgery Study (MASS) II Trial"],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":19,"journal-issue":{"issue":"11_suppl_1","published-print":{"date-parts":[[2012,9,11]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.111.084442"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.111.084442","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]},"assertion":[{"value":"2012-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}