{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:04:07Z","timestamp":1789736647299,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11_suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,9,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Wall stress calculated using finite element analysis has been used to predict rupture risk of aortic aneurysms. Prior models often assume uniform aortic wall thickness and fusiform geometry. We examined the effects of including local wall thickness, intraluminal thrombus, calcifications, and saccular geometry on peak wall stress (PWS) in finite element analysis of descending thoracic aortic aneurysms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Computed tomographic angiography of descending thoracic aortic aneurysms (n=10 total, 5 fusiform and 5 saccular) underwent 3-dimensional reconstruction with custom algorithms. For each aneurysm, an initial model was constructed with uniform wall thickness. Experimental models explored the addition of variable wall thickness, calcifications, and intraluminal thrombus. Each model was loaded with 120 mm\u2009Hg pressure, and von Mises PWS was computed. The mean PWS of uniform wall thickness models was 410\u00b1111 kPa. The imposition of variable wall thickness increased PWS (481\u00b1126 kPa,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Although the addition of calcifications was not statistically significant (506\u00b1126 kPa,\n              <jats:italic>P<\/jats:italic>\n              =0.07), the addition of intraluminal thrombus to variable wall thickness (359\u00b186 kPa,\n              <jats:italic>P<\/jats:italic>\n              \u22640.001) reduced PWS. A final model incorporating all features also reduced PWS (368\u00b188 kPa,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Saccular geometry did not increase diameter-normalized stress in the final model (77\u00b17 versus 67\u00b112 kPa\/cm,\n              <jats:italic>P<\/jats:italic>\n              =0.22).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Incorporation of local wall thickness can significantly increase PWS in finite element analysis models of thoracic aortic aneurysms. Incorporating variable wall thickness, intraluminal thrombus, and calcifications significantly impacts computed PWS of thoracic aneurysms; sophisticated models may, therefore, be more accurate in assessing rupture risk. Saccular aneurysms did not demonstrate a significantly higher normalized PWS than fusiform aneurysms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.112.000200","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T21:37:10Z","timestamp":1379021830000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Impact of Wall Thickness and Saccular Geometry on the Computational Wall Stress of Descending Thoracic Aortic Aneurysms"],"prefix":"10.1161","volume":"128","author":[{"given":"Eric K.","family":"Shang","sequence":"first","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek P.","family":"Nathan","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna R.","family":"Sprinkle","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Fairman","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Bavaria","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gorman","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph H.","family":"Gorman","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Department of Surgery (E.K.S., D.P.N., S.R.S., R.M.F., J.E.B., R.C.G., J.H.G., B.M.J.), Division of Cardiac Surgery (J.E.B., R.C.G., J.H.G.), and Division of Vascular Surgery and Endovascular Therapy (R.M.F., B.M.J.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-0284-4.50043-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.22.1926"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70227-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04147-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.213"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.939819"},{"key":"e_1_3_3_8_2","first-page":"168","article-title":"A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms.","volume":"28","author":"Venkatasubramaniam AK","year":"2004","unstructured":"Venkatasubramaniam AK, Fagan MJ, Mehta T, Mylankal KJ, Ray B, Kuhan G, Chetter IC, McCollum PT. 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