{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:16:55Z","timestamp":1789805815297,"version":"4.0.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,4,23]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US children who received the EXCOR to characterize device outcomes in an unselected cohort and to identify risk factors for mortality to facilitate patient selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>This multicenter, prospective cohort study involved all children implanted with the Berlin Heart EXCOR Pediatric ventricular assist device at 47 centers from May 2007 through December 2010. Multiphase nonproportional hazards modeling was used to identify risk factors for early (&lt;2 months) and late mortality. Of 204 children supported with the EXCOR, the median duration of support was 40 days (range, 1\u2013435 days). Survival at 12 months was 75%, including 64% who reached transplantation, 6% who recovered, and 5% who were alive on the device. Multivariable analysis identified lower weight, biventricular assist device support, and elevated bilirubin as risk factors for early mortality and bilirubin extremes and renal dysfunction as risk factors for late mortality. Neurological dysfunction occurred in 29% and was the leading cause of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Use of the Berlin Heart EXCOR has risen dramatically over the past decade. The EXCOR has emerged as a new treatment standard in the United States for pediatric bridge to transplantation. Three-quarters of children survived to transplantation or recovery; an important fraction experienced neurological dysfunction. Smaller patient size, renal dysfunction, hepatic dysfunction, and biventricular assist device use were associated with mortality, whereas extracorporeal membrane oxygenation before implantation and congenital heart disease were not.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.112.000685","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T23:56:36Z","timestamp":1364514996000},"page":"1702-1711","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":445,"title":["Berlin Heart EXCOR Pediatric Ventricular Assist Device for Bridge to Heart Transplantation in US Children"],"prefix":"10.1161","volume":"127","author":[{"given":"Christopher S.","family":"Almond","sequence":"first","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Morales","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Blackstone","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Turrentine","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Patricia","family":"Massicotte","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori C.","family":"Jordan","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Devaney","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Kanter","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Holman","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kroslowitz","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tjossem","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Thuita","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Buchholz","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"St. Louis","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Niebler","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Henry L.","family":"Walters","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Reemtsen","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Wearden","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Reinhartz","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine J.","family":"Guleserian","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max B.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Bleiweis","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Canter","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Humpl","sequence":"additional","affiliation":[{"name":"From Boston Children\u2019s Hospital, Boston, MA (C.S.A.); Cincinnati Children\u2019s Hospital, Cincinnati, OH (D.L.M.); Heart and Vascular Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH (E.H.B., L.T.); Riley Hospital for Children, Indianapolis, IN (M.W.T.); Arkansas Children\u2019s Hospital, Little Rock (M.I.); Stollery Children\u2019s Hospital, Edmonton, AB, Canada (M.P.M., H.B.); Vanderbilt University Medical Center, Nashville, TN (L.C.J.); C.S. Mott Children\u2019s Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.06.013"},{"key":"e_1_3_3_3_2","unstructured":"HRSA. 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