{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:09:48Z","timestamp":1785816588274,"version":"3.56.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,5,28]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>In the Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study, repeated dietary counseling introduced in infancy and maintained until 20 years of age has led to lower intakes of saturated fat and serum low-density lipoprotein cholesterol. In this study, we examined prospectively the intervention effects on the ideal cardiovascular health concept recently described by the American Heart Association. Additionally, we investigated the association between the concept and vascular intima-media thickness and elasticity in adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      In adolescents participating in the longitudinal, randomized, atherosclerosis-prevention STRIP study, complete data on ideal cardiovascular health metrics were available at 15 (n=394), 17 (n=376), and 19 (n=298) years of age. Aortic intima-media thickness and elasticity were measured with ultrasonography at the same ages. None of the adolescents had all 7 ideal cardiovascular health metrics. At least 5 ideal metrics was found in 60.2%, 45.5%, and 34.2% of the adolescents at 15, 17, and 19 years of age, respectively. Adolescents in the control group had an increased risk of low ideal cardiovascular health (\u22643 metrics) compared with the intervention adolescents (risk ratio=1.35; 95% confidence interval=1.04\u20131.77). The number of ideal cardiovascular health metrics was inversely associated with aortic intima-media thickness (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) and directly associated with elasticity (\n                      <jats:italic>P<\/jats:italic>\n                      =0.045). The risk of having high intima-media thickness (&gt;85th percentile) was nearly 2-fold in adolescents with a low number of metrics (\u22643) compared with those with a higher score (risk ratio=1.78; 95% confidence interval=1.31\u20132.43).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Ideal cardiovascular health as determined by the AHA can be promoted in adolescents. The ideal cardiovascular health concept is beneficially associated with vascular health already in adolescence, supporting the relevance of targeting these metrics as part of primordial prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00223600\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.112.000761","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T21:23:23Z","timestamp":1366752203000},"page":"2088-2096","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":158,"title":["Ideal Cardiovascular Health in Adolescence"],"prefix":"10.1161","volume":"127","author":[{"given":"Katja","family":"Pahkala","sequence":"first","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Hietalampi","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi T.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma S.A.","family":"Viikari","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Niinikoski","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lagstr\u00f6m","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Talvia","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli J.","family":"Heinonen","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Simell","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (K.P., H.H., T.T.L., S.T., M.J., O.S., O.T.R.), Paavo Nurmi Centre, Sports &amp; Exercise Medicine Unit, Department of Physical Activity and Health (K.P., O.J.H.), and Departments of Medicine (J.S.A.V., T.R., M.J.), Pediatrics (H.N., O.S.), and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital; Turku Institute for Child and Youth Research (H.L.); and Institute for Health and..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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