{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:58:56Z","timestamp":1790783936943,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,3,26]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Conduction disturbances are relatively common after transcatheter aortic valve implantation. Previous data demonstrated an adverse impact of persistent left bundle-branch block (LBBB) after surgical aortic valve replacement. It is unclear whether new-onset LBBB may also impact the prognosis of patients after transcatheter aortic valve implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Among 1060 patients treated with a CoreValve Revalving System transcatheter aortic valve implantation between October 2007 and April 2011 in high-volume centers in Italy, we analyzed those without LBBB or pacemaker at admission (879 patients [82.9%]). We further excluded those who underwent permanent pacemaker implantation within 48 hours after the procedure (61 patients [7%]), for a final study population of 818 patients. Among them, 224 patients (group A; 27.4%) developed a persistent LBBB and the remaining 594 (group B; 72.6%) did not. Clinical characteristics were similar between groups. A low implantation was significantly more frequent in group A (15% versus 9.8%,\n              <jats:italic>P<\/jats:italic>\n              =0.02). No patients were censored before 1 year (median follow-up period 438 days, interquartile range 174\u2013798 days). Survival analyses and inherent log-rank tests showed that LBBB was not associated with higher all-cause mortality, cardiac mortality, or hospitalization for heart failure at 30 days or 1 year. At 30 days, but not at 1 year, group A had a significantly higher rate of pacemaker implantation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this registry of high-volume centers, persistent LBBB after CoreValve Revalving System transcatheter aortic valve implantation showed no effect on hard end points. On the other hand, LBBB was associated with a higher short-term rate of pacemaker implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.112.001099","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T10:53:52Z","timestamp":1361962432000},"page":"1300-1307","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":145,"title":["Clinical Impact of Persistent Left Bundle-Branch Block After Transcatheter Aortic Valve Implantation With CoreValve Revalving System"],"prefix":"10.1161","volume":"127","author":[{"given":"Luca","family":"Testa","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Carlo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Agnifili","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Adriano","family":"Latini","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ettori","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Poli","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"De Servi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ramondo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Napodano","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Klugmann","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Ussia","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedy","family":"Brambilla","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Istituto Clinico S. Ambrogio, IRCCS San Donato, Milan, Italy (L.T., M.A., R.A., N.B., F.B.); San Raffaele Hospital, Milan, Italy (A.L., S.K., A.C.); Niguarda Ca Granda Hospital, Milan, Italy (F.D.M.); Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy (M.D.C., A.S.P.); Cardiothoracic Department, Spedali Civili, Brescia, Italy (F.E.); Azienda Ospedaliera Legnano, Legnano, Italy (A.P., S.D.S.); Ospedale di Bassano del Grappa..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq339"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq261"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.253773"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.946533"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.06.012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.055"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20034"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq406"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02211.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ30V6I4A80"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.68.10.403"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1054\/jelc.2000.20330"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00982-X"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.07.006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.845"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808032990501"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00354-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.12.009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.101055"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02337-9"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03009-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00180.x"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.112.001099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:33:50Z","timestamp":1715582030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.112.001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,3,26]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.112.001099"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.112.001099","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,26]]},"assertion":[{"value":"2012-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}