{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:42:39Z","timestamp":1792078959527,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,2,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Hypertrophic cardiomyopathy (HCM) is prominently associated with risk for sudden death and disease progression, largely in young patients. Whether patients of more advanced age harbor similar risks is unresolved, often creating clinical dilemmas, particularly in decisions for primary prevention of sudden death with implantable defibrillators.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We studied 428 consecutive HCM patients presenting at \u226560 years of age and followed for 5.8\u00b14.8 years; 53% were women. Of the 428 patients, 279 (65%) survived to 73\u00b17 years of age (range, 61\u201396 years), most (n=245, 88%) with no\/mild symptoms, including 135 with \u22651 conventional sudden death risk factors and 50 (37%) with late gadolinium enhancement. Over follow-up, 149 (35%) died at 80\u00b18 years of age, mostly from non\u2013HCM-related causes (n=133, 31%), including a substantial proportion from noncardiac disease (n=54). Sixteen patients (3.7%) had HCM-related mortality events (0.64%\/y), including embolic stroke (n=6), progressive heart failure or transplantation (n=3), postoperative complications (n=2), and arrhythmic sudden death events (n=5, 1.2% [0.20%\/y]). All-cause mortality was increased in HCM patients \u226560 years of age compared with an age-matched US general population, predominantly as a result of non\u2013HCM-related diseases (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; standard mortality ratio, 1.5).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>HCM patients surviving into the seventh decade of life are at low risk for disease-related morbidity\/mortality, including sudden death, even with conventional risk factors. These data do not support aggressive prophylactic defibrillator implantation at advanced ages in HCM. Other cardiac or noncardiac comorbidities have a greater impact on survival than HCM in older patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.112.136085","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T01:12:38Z","timestamp":1356916358000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":224,"title":["Risk Stratification and Outcome of Patients With Hypertrophic Cardiomyopathy \u226560 Years of Age"],"prefix":"10.1161","volume":"127","author":[{"given":"Barry J.","family":"Maron","sequence":"first","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan J.","family":"Rowin","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Casey","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy S.","family":"Haas","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H.M.","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross F.","family":"Garberich","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Lesser","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Manning","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN (B.J.M., S.A.C., T.S.H., R.F.G., J.R.L.); Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (E.J.R., J.E.U., M.S.M.); PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA (R.H.M.C., E.A.); and Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.878579"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01003-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422403"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.798314"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq136"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.040"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00855-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.03.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.4.405"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01147.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.090290"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318223e2bd"},{"key":"e_1_3_2_17_2","volume-title":"Expected Survival Base on Hazard Rates (Update), 1999.","author":"Therneau TM","year":"1999","unstructured":"Therneau TM, Offord J. 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