{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:24:13Z","timestamp":1789611853594,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,9,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Assisted reproductive technologies (ARTs) have been shown to be associated with general vascular dysfunction in late childhood. However, it is unknown whether cardiac remodeling is also present and if these changes already manifest in prenatal life. Our aim was to assess fetal and infant (6 months of age) cardiovascular function in ART pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study included 100 fetuses conceived by ART and 100 control pregnancies. ART fetuses showed signs of cardiovascular remodeling, including a more globular heart with thicker myocardial walls, decreased longitudinal function (tricuspid ring displacement in controls: median, 6.5 mm [interquartile range, 6.1\u20137.1 mm]; tricuspid ring displacement in ART: 5.5 mm [interquartile range, 5.1\u20136.1];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), impaired relaxation, and dilated atria (atrial area in controls, 1.46 cm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 1.2\u20131.5 cm\n                      <jats:sup>2<\/jats:sup>\n                      ]; atrial area in ART, 1.6 cm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 1.3\u20131.8 cm\n                      <jats:sup>2<\/jats:sup>\n                      ];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Additionally, ART infants showed persistence of most cardiac changes and a significant increase in blood pressure and aortic intima-media thickness (systolic blood pressure in controls, 74 mm Hg [interquartile range, 67\u201383 mm Hg]; systolic blood pressure in ART, 83 mm Hg [interquartile range, 75\u201394 mm Hg];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001; aortic intima-media thickness in controls, 0.52 mm [interquartile range, 0.45\u20130.56 mm]; aortic intima-media thickness in ART, 0.64 mm [interquartile range, 0.62\u20130.67];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). We could not demonstrate that our findings were directly caused by ART because of their association with various confounding factors, including intrauterine growth restriction or factors related to the cause of infertility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Children conceived by ART manifest cardiac and vascular remodeling that is present in fetal life and persists in postnatal life, suggesting opportunities for early detection and potential intervention. The underlying mechanisms and the effect of potential confounders such as growth restriction or prematurity remain to be elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.113.002428","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T22:01:20Z","timestamp":1377727280000},"page":"1442-1450","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":146,"title":["Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally"],"prefix":"10.1161","volume":"128","author":[{"given":"Brenda","family":"Valenzuela-Alcaraz","sequence":"first","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Bijnens","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cruz-Lemini","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Creus","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Bartrons","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvadora","family":"Civico","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Balasch","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"From the Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, Fetal and Perinatal Medicine Research Group (B.V.-A., F.C., M.C.-L., M.C., S.C., J. Balasch, E.G.) and Cardiology Department, Thorax Institute, Hospital Cl\u00ednic (M.S.), Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, Barcelona, Spain (F.C., E.G.); Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60456-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2012.05.001"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.100479"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323142"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153245"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2432"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.071183"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.937995"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00059-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2832"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8870"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.08.009"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.043919"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.3.271"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00484-X"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.047399"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1023303"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1662"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005155"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.12.015"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.009"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.763"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des252"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.056"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1307417"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.02.131"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.028"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.008"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350699"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.966408"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.179568"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.113.002428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:34:27Z","timestamp":1715567667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.113.002428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,24]]},"references-count":35,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2013,9,24]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.113.002428"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.113.002428","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,24]]},"assertion":[{"value":"2013-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}