{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:30:58Z","timestamp":1781170258619,"version":"3.54.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2013,9,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>We aimed to describe the effects of ticagrelor versus clopidogrel on stent thrombosis in the Platelet Inhibition and Patient Outcomes (PLATO) trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Of 18\u2009624 patients hospitalized for acute coronary syndromes, 11\u2009289 (61%) had at least 1 intracoronary stent. Ticagrelor reduced stent thrombosis compared with clopidogrel across all definitions: definite, 1.37% (n=71) versus 1.93% (n=105; hazard ratio [HR], 0.67; 95% confidence interval [CI], 0.50\u20130.90;\n              <jats:italic>P<\/jats:italic>\n              =0.0091); definite or probable, 2.21% (n=118) versus 2.87% (n=157; HR, 0.75; 95% CI, 0.59\u20130.95;\n              <jats:italic>P<\/jats:italic>\n              =0.017); and definite, probable, and possible, 2.94% (n=154) versus 3.77 (n=201; HR, 0.77; 95% CI, 0.62\u20130.95). The reduction in definite stent thrombosis was consistent regardless of acute coronary syndrome type, presence of diabetes mellitus, stent type (drug-eluting or bare metal stent), CYP2C19 genetic status, loading dose of aspirin, dose of clopidogrel before randomization, and use of glycoprotein IIb\/IIIa inhibitors at randomization. The reduction in stent thrombosis with ticagrelor was numerically greater for late (&gt;30 days; HR, 0.48; 95% CI, 0.24\u20130.96) and subacute (4 hours\u201330 days; HR, 0.60; 95% CI, 0.39\u20130.93) compared with acute (&lt;24 hours; HR, 0.94; 95% CI, 0.43\u20132.05) stent thrombosis or for patients compliant to therapy (ie, taking blinded study treatment \u226580% of the time) compared with less compliant patients. Randomization to ticagrelor was a strong independent inverse predictor of definite stent thrombosis (HR, 0.65; 95% CI, 0.48\u20130.88).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Ticagrelor compared with clopidogrel reduces the incidence of stent thrombosis in patients with acute coronary syndromes, with consistent benefit across a broad range of patient, stent, and treatment characteristics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00391872.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.113.002589","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T01:53:21Z","timestamp":1375235601000},"page":"1055-1065","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Stent Thrombosis With Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes"],"prefix":"10.1161","volume":"128","author":[{"given":"P. Gabriel","family":"Steg","sequence":"first","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Harrington","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Emanuelsson","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Meier","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Wojdyla","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); Medizinische Klinik, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany (H.A.K.); Duke Clinical Research Institute, Duke University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[{"name":"From INSERM-Unit\u00e9 698, Paris, France (P.G.S.); Assistance Publique-H\u00f4pitaux de Paris, D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Paris, France (P.G.S.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, Paris, France (P.G.S.); Department of Medicine, Stanford University, Stanford, CA (R.A.H.); Astra Zeneca R&amp;D, M\u00f6lndal, Sweden (H.E.); 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