{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:54:21Z","timestamp":1790060061312,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2014,1,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Worldwide clinical practice guidelines for dyslipidemia emphasize allocating statin therapy to those at the highest absolute atherosclerotic cardiovascular disease (CVD) risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>We examined 5534 Multi-Ethnic Study of Atherosclerosis (MESA) participants who were not on baseline medications for dyslipidemia. Participants were classified by baseline coronary artery calcium (CAC) score (&gt;0, \u2265100) and the common clinical scheme of counting lipid abnormalities (LA), including low-density lipoprotein cholesterol \u22653.36 mmol\/L (130 mg\/dL), high-density lipoprotein cholesterol &lt;1.03 mmol\/L (40 mg\/dL) for men or &lt;1.29 mmol\/L (50 mg\/dL) for women, and triglycerides \u22651.69 mmol\/L (150 mg\/dL). Our main outcome measure was incident CVD (myocardial infarction, angina resulting in revascularization, resuscitated cardiac arrest, stroke, cardiovascular death). Over a median follow-up of 7.6 years, more than half of events (55%) occurred in the 21% of participants with CAC \u2265100. Conversely, 65% of events occurred in participants with 0 or 1 LA. In those with CAC \u2265100, CVD rates ranged from 22.7 to 29.5 per 1000 person-years across LA categories. In contrast, with CAC=0, CVD rates ranged from 2.7 to 5.9 per 1000 person-years across LA categories. Individuals with 0 LA and CAC \u2265100 had a higher event rate compared with individuals with 3 LA but CAC=0 (22.7 versus 5.9 per 1000 person-years). Similar results were obtained when we classified LA using data set quartiles of total cholesterol\/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, non\u2013high-density lipoprotein cholesterol, or low-density lipoprotein particle concentration and guideline categories of low-density lipoprotein cholesterol or non\u2013high-density lipoprotein cholesterol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>CAC may have the potential to help match statin therapy to absolute CVD risk. Across the spectrum of dyslipidemia, event rates similar to secondary prevention populations were observed for patients with CAC \u2265100.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.113.003625","type":"journal-article","created":{"date-parts":[[2013,10,20]],"date-time":"2013-10-20T20:08:01Z","timestamp":1382299681000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":231,"title":["Dyslipidemia, Coronary Artery Calcium, and Incident Atherosclerotic Cardiovascular Disease"],"prefix":"10.1161","volume":"129","author":[{"given":"Seth S.","family":"Martin","sequence":"first","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Agatston","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Rivera","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Ouyang","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[{"name":"From the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (S.S.M., M.J.B., P.O., S.R.J., R.S.B., K.N.); Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Radiology, Brigham and Women\u2019s Hospital, Boston, MA (R.B.); South Beach Preventive Cardiology Center, University of Miami, Miami, FL (A.A.); Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL (J.J.R.); Michael E. DeBakey Veterans..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr158"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70715-9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072100"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.461"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.210"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.9624"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182051b4c"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000157730.94423.4b"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341040439"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.03.023"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_3_4_18_2","first-page":"CD004816","article-title":"Statins for the primary prevention of cardiovascular disease.","volume":"1","author":"Taylor F","year":"2013","unstructured":"Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;1:CD004816.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60784-8"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1619"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.9502"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7223.1492"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.03.018"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2437"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.019"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.113.003625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:17:08Z","timestamp":1715570228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.113.003625"}},"subtitle":["Implications for Statin Therapy From the Multi-Ethnic Study of Atherosclerosis"],"short-title":[],"issued":{"date-parts":[[2014,1,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,7]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.113.003625"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.113.003625","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718148980.793485655","asserted-by":"object"}]},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,7]]},"assertion":[{"value":"2013-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}