{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:09:56Z","timestamp":1791407396166,"version":"4.3.3"},"reference-count":78,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2014,3,25]]},"DOI":"10.1161\/circulationaha.113.004555","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:34:10Z","timestamp":1395718450000},"page":"1332-1340","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":197,"title":["Immune Dysregulation and Endothelial Dysfunction in Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"129","author":[{"given":"Alice","family":"Huertas","sequence":"first","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Perros","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ly","family":"Tu","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Cohen-Kaminsky","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dorfm\u00fcller","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Guignabert","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[{"name":"From the Univ. Paris\u2013Sud, Facult\u00e9 de M\u00e9decine, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); AP-HP, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire S\u00e9v\u00e8re, D\u00e9partement Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, H\u00f4pital de Bic\u00eatre, Le Kremlin Bic\u00eatre, F-94270 (A.H., F.P., L.T., S.C.-K., D.M., P.D., C.G., M.H.); UMR_S 999, Univ. Paris\u2013Sud; INSERM; Laboratoire d\u2019Excellence (LabEx) en Recherche sur le M\u00e9dicament et l\u2019Innovation..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.006"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.05.004"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046612"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735624"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1559OC"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.4.2012112"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106007"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.07.006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.038"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.933762"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-1049ED"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00038903"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00094706"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201105-0927OC"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0164OC"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.110619"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1364OC"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.182"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23303"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00133904"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200195"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00181410"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029082"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1015OC"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00164209"},{"key":"e_1_3_4_30_2","first-page":"286","article-title":"High prevalence of antiphospholipid antibodies in precapillary pulmonary hypertension.","volume":"23","author":"Karmochkine M","year":"1996","unstructured":"Karmochkine M, Cacoub P, Dorent R, Laroche P, Nataf P, Piette JC, Boffa MC, Gandjbakhch I. High prevalence of antiphospholipid antibodies in precapillary pulmonary hypertension. J Rheumatol. 1996;23:286\u2013290.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b28.x"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1818"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031579"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.10.004"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111548"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159911"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0307166"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/90667"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0335OC"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1786"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.1072"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61762-2"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00038-3"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11311"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00049.x"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.40.6.405"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62570-9"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4638"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH774>3.0.CO;2-N"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300107"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7830"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2860"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803606"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1543OC"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5735"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.182014"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-6"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028310"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.6.7946395"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030850"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0317OC"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0309OC"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028578"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00045705"},{"key":"e_1_3_4_65_2","first-page":"527","article-title":"Anti-endothelial cell antibodies in systemic sclerosis: significant association with vascular involvement and alveolo-capillary impairment.","volume":"16","author":"Pignone A","year":"1998","unstructured":"Pignone A, Scaletti C, Matucci-Cerinic M, V\u00e1zquez-Abad D, Meroni PL, Del Papa N, Falcini F, Generini S, Rothfield N, Cagnoni M. Anti-endothelial cell antibodies in systemic sclerosis: significant association with vascular involvement and alveolo-capillary impairment. Clin Exp Rheumatol. 1998;16:527\u2013532.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00087212"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0402OC"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.009"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-60"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.1.88"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0905OC"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00493.x"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1189OC"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.236927"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040291"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.104"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.000765"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.001460"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911818"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.113.004555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:38:56Z","timestamp":1715582336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.113.004555"}},"subtitle":["A Complex Interplay"],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":78,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,3,25]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.113.004555"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.113.004555","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]},"assertion":[{"value":"2014-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}