{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:36:58Z","timestamp":1789540618884,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Experience with aortic valve replacement (AVR) with current-generation pericardial bioprostheses in young patients is limited. The death of a child with accelerated bioprosthetic aortic stenosis prompted enhanced surveillance of all such patients at our institution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We reviewed records of 27 patients who had undergone AVR (median follow-up, 13.7 months) with a bovine pericardial bioprosthesis at \u226430 years of age. In the Mitroflow LXA valve group (n=15), freedom from valve failure was 100% at 1 year, 53% (95% confidence interval, 12\u201382) at 2 years, and 18% (95% confidence interval, 1\u201353) at 3 years. No Magna\/Magna Ease valves (n=12) failed by 3 years. Among valve failure patients, median age at AVR was 12 years (range, 10\u201321 years). Life-threatening prosthetic aortic stenosis was detected at a median of 6 months after prior echocardiograms showing mild or less gradients. Patients with Mitroflow LXA compared with Magna\/Magna Ease valves were smaller (median body surface area, 1.42 versus 1.93 m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.002) and younger (median age, 13.0 versus 20.9 years;\n              <jats:italic>P<\/jats:italic>\n              =0.02) at AVR. Pathology demonstrated diffuse intrinsic leaflet calcification, not associated with inflammation or infection, and virtually immobile leaflets in closed position.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Young patients undergoing AVR with Mitroflow LXA pericardial valves are at high risk for rapid progression from mild or less to severe aortic stenosis over months, highlighting their need for heightened echocardiographic surveillance and suggesting that this aortic bioprosthesis should not be implanted in the young. Current data are insufficient to assess the safety of AVR with other pericardial bioprostheses in children and the youngest adults.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.114.009835","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T06:57:19Z","timestamp":1398236239000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":125,"title":["Accelerated Degeneration of a Bovine Pericardial Bioprosthetic Aortic Valve in Children and Young Adults"],"prefix":"10.1161","volume":"130","author":[{"given":"Susan F.","family":"Saleeb","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Geva","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Baird","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Padera","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"del Nido","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele J.","family":"Borisuk","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Sanders","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Mayer","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.F.S., J.W.N., T.G., K.G., S.P.S.) and Cardiac Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), Boston Children\u2019s Hospital, Boston, MA; Departments of Pediatrics (S.F.S., J.W.N., T.G., K.G., S.P.S.), Surgery (C.W.B., P.J.d.N., M.J.B., J.E.M.), and Pathology (R.F.P.), Harvard Medical School, Boston, MA; and Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA (R.F.P)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"MedSun: Newsletter 92 February 2014. http:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/medsun\/news\/newsletter.cfm?news=92#4. 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Long-term outcomes of the Carpentier-Edwards pericardial valve prosthesis in the aortic position: effect of patient age. J Heart Valve Dis. 2004;13(suppl 1):S49\u2013S51.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01129-1"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.022"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.541649"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.06.092"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.204958"},{"key":"e_1_3_4_30_2","unstructured":"US Food and Drug Administration. Medical devices.http:\/\/www.fda.gov\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/ucm339162.htm#4. 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