{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:27:08Z","timestamp":1791210428450,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2014,9,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying diseases such as HIV infection, results from complex vessel remodeling involving both pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation. CCR5, a coreceptor for cellular HIV-1 entry expressed on macrophages and vascular cells, may be involved in the pathogenesis of PH. Maraviroc is a new CCR5 antagonist designed to block HIV entry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Marked CCR5 expression was found in lungs from patients with idiopathic PH, in mice with hypoxia-induced PH, and in Simian immunodeficiency virus\u2013infected macaques, in which it was localized chiefly in the PA-SMCs. To assess the role for CCR5 in experimental PH, we used both gene disruption and pharmacological CCR5 inactivation in mice. Because maraviroc does not bind to murine CCR5, we used human-CCR5ki mice for pharmacological and immunohistochemical studies. Compared with wild-type mice, CCR5\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice or human-CCR5ki mice treated with maraviroc exhibited decreased PA-SMC proliferation and recruitment of perivascular and alveolar macrophages during hypoxia exposure. CCR5\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice reconstituted with wild-type bone marrow cells and wild-type mice reconstituted with CCR5\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              bone marrow cells were protected against PH, suggesting CCR5-mediated effects on PA-SMCs and macrophage involvement. The CCR5 ligands CCL5 and the HIV-1 gp120 protein increased intracellular calcium and induced growth of human and human-CCR5ki mouse PA-SMCs; maraviroc inhibited both effects. Maraviroc also reduced the growth-promoting effects of conditioned media from CCL5-activated macrophages derived from human-CCR5ki mice on PA-SMCs from wild-type mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>The CCL5-CCR5 pathway represents a new therapeutic target in PH associated with HIV or with other conditions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.114.010757","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T05:38:39Z","timestamp":1404452319000},"page":"880-891","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["CCR5 as a Treatment Target in Pulmonary Arterial Hypertension"],"prefix":"10.1161","volume":"130","author":[{"given":"Val\u00e9rie","family":"Amsellem","sequence":"first","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Lipskaia","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shariq","family":"Abid","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Poupel","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Houssaini","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn","family":"Quarck","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Marcos","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mouraret","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Parpaleix","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bobe","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gary-Bobo","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Saker","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Dubois-Rand\u00e9","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Norris","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Delcroix","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Combadi\u00e8re","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Adnot","sequence":"additional","affiliation":[{"name":"From Inserm U955 and D\u00e9partement de Physiologie (V.A., L.L., S.A., A.H., E.M., N.M., A.P., G.G.-B., M.S., S.A.) and Service de Cardiologie (J.-L.D.-R.), H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France; Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, CR7 (L.P., C.C.), Inserm, U1135 (C.C.), and CNRS, ERL 8255 (C.C.), Centre d\u2019Immunologie et des Maladies Infectieuses, Paris, France; Respiratory Division, University Hospitals of Leuven and Department of Clinical and Experimental..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2006.11.010"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-541OC"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.018"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.161224"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052723"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1559OC"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106007"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.4.2012112"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/381667a0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/381661a0"},{"key":"e_1_3_4_14_2","first-page":"151","article-title":"Maraviroc in the treatment of HIV infection.","volume":"2","author":"Ray N","year":"2009","unstructured":"Ray N. Maraviroc in the treatment of HIV infection. Drug Des Devel Ther. 2009;2:151\u2013161.","journal-title":"Drug Des Devel Ther"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.12.002"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5466"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43027"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.745091"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600330"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.9.6296-6304.1997"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00045.2011"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.07.019"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)05202-1"},{"key":"e_1_3_4_24_2","unstructured":"R W Mansfield CMN H E Sale M J Mosley G Rickett P Dorr M Perros. UK-472 857 binding characteristics to human and animal recombinant CCR5 receptors. Poster Exhibition: The XV International AIDS Conference: Abstract no. WePeA5640."},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0434OC"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000231527.22762.71"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.002434"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.978627"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.12.016"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.113.302302"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.50"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000243584.45145.3f"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00104706"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0182OC"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/605695"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.973750"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.114.010757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:37:24Z","timestamp":1715582244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.114.010757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,9]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,9,9]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.114.010757"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.114.010757","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,9]]},"assertion":[{"value":"2013-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}