{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:17:57Z","timestamp":1790745477421,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2015,3,24]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In comparison with men, women have a better prognosis when experiencing aortic valve stenosis, hypertrophic cardiomyopathy, or heart failure. Recent data suggest that androgens like testosterone or the more potent dihydrotestosterone contribute to the development of cardiac hypertrophy and failure. Therefore, we analyzed whether antiandrogenic therapy with finasteride, which inhibits the generation of dihydrotestosterone by the enzyme 5-\u03b1-reductase, improves pathological ventricular remodeling and heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>We found a strongly induced expression of all 3 isoforms of the 5-\u03b1-reductase (Srd5a1 to Srd5a3) in human and mouse hearts with pathological hypertrophy, which was associated with increased myocardial accumulation of dihydrotestosterone. Starting 1 week after the induction of pressure overload by transaortic constriction, mice were treated with finasteride for 2 weeks. Cardiac function, hypertrophy, dilation, and fibrosis were markedly improved in response to finasteride treatment in not only male, but also in female mice. In addition, finasteride also very effectively improved cardiac function and mortality after long-term pressure overload and prevented disease progression in cardiomyopathic mice with myocardial G\u03b1q overexpression. Mechanistically, finasteride, by decreasing dihydrotestosterone, potently inhibited hypertrophy and Akt-dependent prohypertrophic signaling in isolated cardiac myocytes, whereas the introduction of constitutively active Akt blunted these effects of finasteride.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Finasteride, which is currently used in patients to treat prostate disease, potently reverses pathological cardiac hypertrophy and dysfunction in mice and might be a therapeutic option for heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.114.012066","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T06:52:55Z","timestamp":1422514375000},"page":"1071-1081","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction"],"prefix":"10.1161","volume":"131","author":[{"given":"Carolin","family":"Zwadlo","sequence":"first","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Schmidtmann","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Szaroszyk","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badder","family":"Kattih","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Froese","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebke","family":"Hinz","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Dieter","family":"Schmitto","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Widder","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Batkai","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"B\u00e4hre","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkhard","family":"Kaever","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Heineke","sequence":"additional","affiliation":[{"name":"From Medizinische Hochschule Hannover, Klinik f\u00fcr Kardiologie und Angiologie, Hanover, Germany (C.Z., E.S., M.S., B.K., N.F., H.H., J.W., J.B., J.H.); Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie, Hanover, Germany (J.D.S.); Institut f\u00fcr Molekulare und Translationale Therapiestrategien (IMTTS), Hannover, Germany (S.B., T.T.); National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.); and Medizinische Hochschule Hannover, Zentrale Forschungseinrichtung..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192667"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs109"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163156"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19429"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.3.256"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39266.425069.AD"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.7.7608272"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2007.10.005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01087.2002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411694200"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.01.024"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(90)90487-6"},{"key":"e_1_3_3_17_2","first-page":"293","article-title":"Human type 3 5-alpha-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride.","volume":"2","author":"Yamana K","year":"2010","unstructured":"Yamana K, Labrie F, Luu-The V. 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