{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:08:48Z","timestamp":1790482128884,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2015,1,20]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Knowledge of mitral valve prolapse (MVP) inheritance is based on pedigree observation and M-mode echocardiography. The extent of familial clustering of MVP among unselected individuals in the community using current, more specific echocardiographic criteria is unknown. In addition, the importance of nondiagnostic MVP morphologies (NDMs; first described in large pedigrees) has not been investigated in the general population. We hypothesized that parental MVP and NDMs increase the risk of offspring MVP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Study participants were 3679 Generation 3 individuals with available parental data in the Offspring or the New Offspring Spouse cohorts. MVP and NDMs were distinguished by leaflet displacement &gt;2 versus \u22642 mm beyond the mitral annulus, respectively. We compared MVP prevalence in Generation 3 participants with at least 1 parent with MVP (n=186) with that in individuals without parental MVP (n=3493). Among 3679 participants (53% women; mean age, 40\u00b19 years), 49 (1%) had MVP. Parental MVP was associated with a higher prevalence of MVP in Generation 3 participants (10 of 186, 5.4%) compared with no parental MVP (39 of 3493, 1.1%; adjusted odds ratio, 4.51; 95% confidence interval, 2.13\u20139.54;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). When parental NDMs were examined alone, the prevalence of Generation 3 MVP remained higher (12 of 484, 2.5%) compared with those without parental MVP or NDMs (27 of 3009, 0.9%; adjusted odds ratio, 2.52; 95% confidence interval, 1.25\u20135.10;\n              <jats:italic>P<\/jats:italic>\n              =0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Parental MVP and NDMs are associated with increased prevalence of offspring MVP, highlighting the genetic substrate of MVP and the potential clinical significance of NDMs in the community.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.114.012594","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T05:43:51Z","timestamp":1414820631000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Familial Clustering of Mitral Valve Prolapse in the Community"],"prefix":"10.1161","volume":"131","author":[{"given":"Francesca N.","family":"Delling","sequence":"first","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Rong","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Larson","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Lehman","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Osypiuk","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Plamen","family":"Stantchev","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Slaugenhaupt","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Levine","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"From Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, Framingham, MA (F.N.D., J.R., M.G.L., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D.); Section of Neurology (J.R.), Section of Cardiology (E.J.B., R.S.V.), and Preventive Medicine (E.J.B., R.S.V.) sections in the Department of Medicine, Boston University School of Medicine, Boston, MA;..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410101"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00981-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02161-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90204-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4601.099489"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90397-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)90059-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.4.756"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041451"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00313-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.10.029"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90955-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904203201602"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90961-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90590-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80718-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000028933.34260.09"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2007.12.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611073351902"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60692-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.35.3.245"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.39.3.327"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-6-826"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00865.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90015-5"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.6.1091"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80233-0"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/302624"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/375452"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.516930"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.622621"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.09.015"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112813"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm021"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2013.04.003"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90491-4"},{"key":"e_1_3_3_39_2","first-page":"1013","article-title":"Genetic aspects of valvulopathies [in French].","volume":"100","author":"Kyndt F","year":"2007","unstructured":"Kyndt F, Le Scouarnec S, Jaafar P, Gueffet JP, Legendre A, Trochu JN, Jousseaume V, Chaventr\u00e9 A, Schott JJ, Le Marec H, Probst V. Genetic aspects of valvulopathies [in French]. Arch Mal Coeur Vaiss. 2007;100:1013\u20131020.","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00454-8"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.114.012594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:33:19Z","timestamp":1715581999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.114.012594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,1,20]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.114.012594"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.114.012594","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,20]]},"assertion":[{"value":"2014-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}