{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:01:23Z","timestamp":1791597683937,"version":"4.3.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2015,11,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The goal of this work was to assess the safety and efficacy of biologics (ie, tumor necrosis factor-\u03b1 antagonists and tocilizumab) in patients with Takayasu arteritis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This was a retrospective, multicenter study of the characteristics and outcomes of 49 patients with Takayasu arteritis (80% female; median age, 42 years [20\u201355 years] treated by tumor necrosis factor-\u03b1 antagonists [80%] or tocilizumab [20%]) and fulfilling American College of Rheumatology or Ishikawa criteria. Factors associated with complete response were assessed. Eighty-eight percent of patients with Takayasu arteritis were inadequately controlled with or were intolerant to conventional immunosuppressive therapy (median number, 3 [1\u20135]). Overall response (ie, complete and partial) to biological-targeted treatments at 6 and 12 months was 75% and 83%, respectively. There were significantly lower C-reactive protein levels at the initiation of biological-targeted treatments (22 mg\/L [10\u201346 mg\/L] versus 58 mg\/L [26\u201376 mg\/L];\n              <jats:italic>P<\/jats:italic>\n              =0.006) and a trend toward fewer immunosuppressants drugs used before biologics (\n              <jats:italic>P<\/jats:italic>\n              =0.054) in responders (ie, complete or partial responders) relative to nonresponders to biological-targeted treatments. C-reactive protein levels and daily prednisone dose significantly decreased after 12 months of biological-targeted treatments (30 versus 6 mg\/L [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05] and 15 versus 7.5 mg [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05] at baseline and 12 months, respectively). The 3-year relapse-free survival was 90.9% (83.5%\u201399%) over the biological treatment period compared with 58.7% (43.3%\u201379.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.0025) with disease-modifying antirheumatic drugs. No difference in efficacy was found between tumor necrosis factor-\u03b1 antagonists and tocilizumab. After a median follow-up of 24 months (2\u201395 months), 21% of patients experienced adverse effects, with biological-targeted treatments discontinued in 6.6% of cases.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>This nationwide study shows a high efficacy of biological-targeted treatments in refractory patients with Takayasu arteritis with an acceptable safety profile.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.114.014321","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T13:59:11Z","timestamp":1441893551000},"page":"1693-1700","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":167,"title":["Efficacy of Biological-Targeted Treatments in Takayasu Arteritis"],"prefix":"10.1161","volume":"132","author":[{"given":"Arsene","family":"Mekinian","sequence":"first","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clo\u00e9","family":"Comarmond","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Resche-Rigon","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Mirault","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Emmanuel","family":"Kahn","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lambert","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Sibilia","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"N\u00e9el","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cohen","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Hie","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Berthier","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Marie","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lavigne","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Anne Vandenhende","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Muller","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahir","family":"Amoura","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Devilliers","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Abad","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hamidou","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Guillevin","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Dhote","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Godeau","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Messas","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Cacoub","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fain","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saadoun","sequence":"additional","affiliation":[{"name":"From AP-HP, H\u00f4pital Saint Antoine, Service de M\u00e9decine Interne et Inflammation-Immunopathology\u2013Biotherapy Department (DHU i2B), Paris, France (A.M., O.F.); Service de M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salpetri\u00e8re, Universit\u00e9 Paris 6, Paris, France (C.C., P. Cacoub, D.S.); Unit\u00e9 Epid\u00e9miologie et Biostatistiques, INSERM, H\u00f4pital Saint Louis, Paris, France (M.R.-R.); Service de M\u00e9decine Vasculaire, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris\u2013APHP, Universit\u00e9 Paris Descartes,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-11-199406010-00004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370420"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02701-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.759589"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.08.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.019"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1384"},{"key":"e_1_3_3_10_2","first-page":"S98","article-title":"One-year clinical and radiological evolution of a patient with refractory Takayasu\u2019s arteritis under treatment with tocilizumab.","volume":"30","author":"Bredemeier M","year":"2012","unstructured":"Bredemeier M, Rocha CM, Barbosa MV, Pitrez EH. One-year clinical and radiological evolution of a patient with refractory Takayasu\u2019s arteritis under treatment with tocilizumab. Clin Exp Rheumatol. 2012;30(suppl 70):S98\u2013100.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.11.025"},{"key":"e_1_3_3_12_2","first-page":"951","article-title":"Streptococcal lung abscesses from a dental focus following tocilizumab: a case report.","volume":"30","author":"de Kruif MD","year":"2012","unstructured":"de Kruif MD, van Gorp EC, Bel EH, Gerlag DM, Kunst PW. Streptococcal lung abscesses from a dental focus following tocilizumab: a case report. Clin Exp Rheumatol. 2012;30:951\u2013953.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12220"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20300"},{"key":"e_1_3_3_15_2","first-page":"63","article-title":"Refractory Takayasu arteritis successfully treated with infliximab.","volume":"13","author":"Maffei S","year":"2009","unstructured":"Maffei S, Di Renzo M, Santoro S, Puccetti L, Pasqui AL. Refractory Takayasu arteritis successfully treated with infliximab. Eur Rev Med Pharmacol Sci. 2009;13:63\u201365.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker380"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093260"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.54.405"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23373"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042010000300009"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1658-1"},{"key":"e_1_3_3_22_2","first-page":"S90","article-title":"Rescue treatment with tocilizumab for Takayasu arteritis resistant to TNF-\u03b1 blockers.","volume":"30","author":"Salvarani C","year":"2012","unstructured":"Salvarani C, Magnani L, Catanoso MG, Pipitone N, Versari A, Dardani L, Pulsatelli L, Meliconi R, Boiardi L. Rescue treatment with tocilizumab for Takayasu arteritis resistant to TNF-\u03b1 blockers. Clin Exp Rheumatol. 2012;30(suppl 70):S90\u2013S93.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21636"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2011.13156"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130536"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21750"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.012"},{"key":"e_1_3_3_28_2","first-page":"S86","article-title":"Assessment of disease activity and progression in Takayasu\u2019s arteritis.","volume":"29","author":"Direskeneli H","year":"2011","unstructured":"Direskeneli H, Aydin SZ, Merkel PA. Assessment of disease activity and progression in Takayasu\u2019s arteritis. Clin Exp Rheumatol. 2011;29(suppl 64):S86\u2013S91.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22404"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.149419"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.10857"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.114.014321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:54:45Z","timestamp":1715583285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.114.014321"}},"subtitle":["Multicenter, Retrospective Study of 49 Patients"],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":33,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,11,3]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.114.014321"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.114.014321","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]},"assertion":[{"value":"2014-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}