{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:26:56Z","timestamp":1791239216856,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The mechanism(s) of persistent and long-standing persistent (LSP) atrial fibrillation (AF) is\/are poorly understood. We performed high-density, simultaneous, biatrial, epicardial mapping of persistent and LSP AF in patients undergoing open heart surgery (1) to test the hypothesis that persistent and LSP AF are due to \u22651 drivers, either focal or reentrant, and (2) to characterize associated atrial activation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Twelve patients with persistent and LSP AF (1 month to 9 years duration) were studied at open heart surgery. During AF, electrograms were recorded from both atria simultaneously for 1 to 5 minutes from 510 to 512 epicardial electrodes with ECG lead II. Thirty-two consecutive seconds of activation sequence maps were produced per patient. During AF, multiple foci (QS unipolar atrial electrograms) of different cycle lengths (mean, 175\u00b118 ms) were present in both atria in 11 of 12 patients. Foci (2\u20134 per patient, duration 5\u201332 s) were either sustained or intermittent, were predominantly found in the lateral left atrial free wall, and likely acted as drivers. Random and nonrandom breakthrough activation sites (initial r or R in unipolar atrial electrograms) were also found. In 1 of 12 patients, only breakthrough sites were found. All wave fronts emanated from foci and breakthrough sites, and largely either collided or merged with each other at variable sites. Repetitive focal QS activation occasionally generated repetitive wannabe reentrant activation in 5 of 12 patients. No actual reentry was found.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>During persistent and LSP AF in 12 patients, wave fronts emanating from foci and breakthrough sites maintained AF. No reentry was demonstrated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.115.017007","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T02:08:53Z","timestamp":1445652533000},"page":"2108-2117","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":154,"title":["Simultaneous Biatrial High-Density (510\u2013512 Electrodes) Epicardial Mapping of Persistent and Long-Standing Persistent Atrial Fibrillation in Patients"],"prefix":"10.1161","volume":"132","author":[{"given":"Seungyup","family":"Lee","sequence":"first","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar","family":"Sahadevan","sequence":"additional","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeen M.","family":"Khrestian","sequence":"additional","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Cakulev","sequence":"additional","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Markowitz","sequence":"additional","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert L.","family":"Waldo","sequence":"additional","affiliation":[{"name":"From Departments of Medicine and Surgery, Case Western Reserve University (S.L., J.S., C.M.K., I.C., A.L.W.); Division of Cardiovascular Medicine, Case Western Reserve University (J.S., I.C., A.L.W.); and Valve Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center; Cleveland, OH (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00613-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015233"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01091-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00571.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03696-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.05.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147781.02738.13"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.517011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.945709"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.910901"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005421"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht267"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12559"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.002721"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12014"},{"key":"e_1_3_3_20_2","first-page":"43","article-title":"On circulating excitations in heart muscles and their possible relation to tachycardia and fibrillation.","volume":"8","author":"Mines GR.","year":"1914","unstructured":"Mines GR. On circulating excitations in heart muscles and their possible relation to tachycardia and fibrillation. Trans R Soc Can. 1914;8:43\u201352.","journal-title":"Trans R Soc Can"}],"updated-by":[{"DOI":"10.1161\/cir.0000000000000377","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000}}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.115.017007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:44:08Z","timestamp":1715582648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.115.017007"}},"subtitle":["New Insights Into the Mechanism of Its Maintenance"],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":18,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.115.017007"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.115.017007","relation":{"correction":[{"id-type":"doi","id":"10.1161\/CIR.0000000000000377","asserted-by":"object"}]},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"2015-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}