{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:55:39Z","timestamp":1792166139632,"version":"4.4.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2015,10,13]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Inflammatory processes have been identified as key mediators of the deleterious effects of ischemia\/reperfusion in ST-segment\u2013elevation myocardial infarction. Colchicine is a substance with potent anti-inflammatory properties, suitable for safe use in patients with cardiovascular disease. The purpose of this study was to test the hypothesis that a short course of colchicine treatment could lead to reduced infarct size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      Patients presenting with ST-segment\u2013elevation myocardial infarction \u226412 hours from pain onset (treated with primary percutaneous coronary intervention) were randomly assigned to colchicine or placebo for 5 days. The primary outcome parameter was the area under the curve of creatine kinase-myocardial brain fraction concentration. A subset of patients underwent cardiac MRI with late gadolinium enhancement 6 to 9 days after the index ST-segment\u2013elevation myocardial infarction. One hundred fifty-one patients were included (60 in the MRI substudy). The area under the creatine kinase-myocardial brain fraction curve was 3144 (interquartile range [IQR], 1754\u20136940) ng\u00b7h\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00b7mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      in the colchicine group in comparison with 6184 (IQR, 4456\u20136980) ng\u00b7h\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00b7mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      in controls (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Indexed MRI-late gadolinium enhancement\u2013defined infarct size was 18.3 (IQR, 7.6\u201329.9) mL\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      in the colchicine group versus 23.2 (18.5\u201333.4) mL\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      in controls (\n                      <jats:italic>P<\/jats:italic>\n                      =0.019). The relative infarct size (as a proportion to left ventricular myocardial volume) was 13.0 (IQR, 8.0\u201325.3) % and 19.8 (IQR, 13.7\u201329.8) %, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      =0.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>These results suggest a potential benefit of colchicine in ST-segment\u2013elevation myocardial infarction, but further clinical trials are necessary to draw secure conclusions, especially considering the fact that the present study was not powered to assess clinical end points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT01936285.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.115.017611","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T22:39:38Z","timestamp":1439332778000},"page":"1395-1403","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":265,"title":["Anti-Inflammatory Treatment With Colchicine in Acute Myocardial Infarction"],"prefix":"10.1161","volume":"132","author":[{"given":"Spyridon","family":"Deftereos","sequence":"first","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Angelidis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Papoutsidakis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sianos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Goudevenos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasios","family":"Pyrgakis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Cleman","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis S.","family":"Manolis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. Gennimatas\u201d, Greece (S.D., G.G., C.A., N.P., V.P.); 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece (S.D., G.G., G.F., J.L.); Cardiology Department, Athens Euroclinic, Greece (N.A.); AHEPA University Hospital, Thessaloniki, Greece (G.S.); 1st Department of Cardiology, University of Ioannina Medical School, Greece (J.G.); Cardiology Department, University of Patras, Greece (D.A.); Section..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lekakis","sequence":"additional","affiliation":[{"name":"From Department of Cardiology, Athens General Hospital \u201cG. 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