{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:30:13Z","timestamp":1791563413972,"version":"4.3.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2016,1,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Less than one-third of smokers hospitalized with an acute coronary syndrome (ACS) remain abstinent following discharge. We assessed whether varenicline, begun in-hospital, is efficacious for smoking cessation following ACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We conducted a multi-center, double-blind, randomized, placebo-controlled trial in which smokers hospitalized with an ACS were randomized to varenicline or placebo for 12 weeks. All patients received low-intensity counseling. The primary end point was point-prevalence smoking abstinence assessed at 24 weeks by 7-day recall and biochemical validation using expired carbon monoxide. A total of 302 patients were randomized (mean age 55\u00b19 years; 75% male; 56% ST-segment elevation myocardial infarction; 38% non-ST-segment elevation myocardial infarction; 6% unstable angina). Patients smoked a mean of 21\u00b111 cigarettes\/d at the time of hospitalization and had been smoking for a mean of 36\u00b112 years. At 24 weeks, patients randomized to varenicline had significantly higher rates of smoking abstinence and reduction than patients randomized to placebo. Point-prevalence abstinence rates were 47.3% in the varenicline group and 32.5% in the placebo group (\n              <jats:italic>P<\/jats:italic>\n              =0.012; number needed to treat=6.8). Continuous abstinence rates were 35.8% and 25.8%, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.081; number needed to treat=10.0), and rates of reduction \u226550% in daily cigarette consumption were 67.4% and 55.6%, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.05; number needed to treat=8.5). Adverse event rates within 30 days of study drug discontinuation were similar between groups (serious adverse events: varenicline 11.9%, placebo 11.3%; major adverse cardiovascular events: varenicline 4.0%, placebo 4.6%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Varenicline, initiated in-hospital following ACS, is efficacious for smoking cessation. Future studies are needed to establish safety in these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00794573.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.115.019634","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T03:48:52Z","timestamp":1447127332000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["Varenicline for Smoking Cessation in Hospitalized Patients With Acute Coronary Syndrome"],"prefix":"10.1161","volume":"133","author":[{"given":"Mark J.","family":"Eisenberg","sequence":"first","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Windle","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Roy","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Old","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois R.","family":"Grondin","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Bata","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Iskander","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Lauzon","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalin","family":"Srivastava","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Clarke","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cassavar","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Dion","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); 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Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Baril","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); Centre de sant\u00e9 et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudi\u00e8re-Appalaches, H\u00f4tel-Dieu de L\u00e9vis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph\u2019s Hospital, Liverpool, NY (A.I.); CISSS - Chaudi\u00e8re-Appalaches, Thetford Mines, QC..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lambert","sequence":"additional","affiliation":[{"name":"From Jewish General Hospital\/McGill University, Montr\u00e9al, QC, Canada (M.J.E., S.B.W.); 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