{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:24:13Z","timestamp":1791685453706,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2016,4,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Surgical risk scores do not include frailty assessments (eg, gait speed), which are of particular importance for patients with severe aortic stenosis considering transcatheter aortic valve replacement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We assessed the association of 5-m gait speed with outcomes in a cohort of 8039 patients who underwent transcatheter aortic valve replacement (November 2011\u2013June 2014) and were included in the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry. We evaluated the association between continuous and categorical gait speed and 30-day all-cause mortality before and after adjustment for Society of Thoracic Surgeons\u2013predicted risk of mortality score and key variables. Secondary outcomes included in-hospital mortality, bleeding, acute kidney injury, and stroke. The overall median gait speed was 0.63 m\/s (25th\u201375th percentile, 0.47\u20130.79 m\/s), with the slowest walkers (&lt;0.5 m\/s) constituting 28%, slow walkers (0.5\u20130.83 m\/s) making up 48%, and normal walkers (&gt;0.83 m\/s) constituting 24% of the population. Thirty-day all-cause mortality rates were 8.4%, 6.6%, and 5.4% for the slowest, slow, and normal walkers, respectively (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Each 0.2-m\/s decrease in gait speed corresponded to an 11% increase in 30-day mortality (adjusted odds ratio, 1.11; 95% confidence interval, 1.01\u20131.22). The slowest walkers had 35% higher 30-day mortality than normal walkers (adjusted odds ratio, 1.35; 95% confidence interval, 1.01\u20131.80), significantly longer hospital stays, and a lower probability of being discharged to home.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Gait speed is independently associated with 30-day mortality after transcatheter aortic valve replacement. Identification of frail patients with the slowest gait speeds facilitates preprocedural evaluation and anticipation of a higher level of postprocedural care.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01737528.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.115.020279","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T04:09:26Z","timestamp":1456546166000},"page":"1351-1359","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":117,"title":["Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"133","author":[{"given":"Joakim","family":"Alfredsson","sequence":"first","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Stebbins","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Matthew","family":"Brennan","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Matsouaka","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Afilalo","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Rumsfeld","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shahian","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston (D.S.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen P.","family":"Alexander","sequence":"additional","affiliation":[{"name":"From Duke Clinical Research Institute, Durham, NC (J. Alfredsson, A.S., E.D.P., K.P.A.); Department of Cardiology and Department of Medical and Health Sciences, Link\u00f6ping University, Sweden (J. Alfredsson); Duke University School of Medicine, Durham, NC (J.M.B., R.M., E.D.P., S.V., K.P.A.); Division of Cardiology, Jewish General Hospital, McGill University, Montreal, QC, Canada (J. Afilalo); University of Colorado School of Medicine, Aurora (J.S.R.); Massachusetts General Hospital, Boston 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From the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry"],"short-title":[],"issued":{"date-parts":[[2016,4,5]]},"references-count":39,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016,4,5]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.115.020279"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.115.020279","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,5]]},"assertion":[{"value":"2015-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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