{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:47Z","timestamp":1791346667041,"version":"4.3.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2016,9,27]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Although a blood genetic disease, sickle cell disease (SCD) leads to a chronic vasculopathy with multiple organ involvement. We assessed arterial stiffness in SCD patients and looked for associations between arterial stiffness and SCD-related vascular complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The CADRE (Coeur Art\u00e8res et Drepanocytose, ie, Heart Arteries and Sickle Cell Disease) study prospectively recruited pediatric and adult SCD patients and healthy controls in Cameroon, Ivory Coast, Gabon, Mali, and Senegal. Patients underwent clinical examination, routine laboratory tests (complete blood count, serum creatinine level), urine albumin\/creatinine ratio measure, and a measure of carotid-femoral pulse wave velocity (cf-PWV) and augmentation index (AI) at a steady state. The clinical and biological correlates of cf-PWV and AI were investigated by using a multivariable multilevel linear regression analysis with individuals nested in families further nested in countries.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Included were 3627 patients with SCD and 943 controls. Mean cf-PWV was lower in SCD patients (7.5\u00b12.0 m\/s) than in controls (9.1\u00b12.4 m\/s,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), and lower in SS-S\u03b2\n              <jats:sup>0<\/jats:sup>\n              than in SC-S\u03b2\n              <jats:sup>+<\/jats:sup>\n              phenotypes. AI, corrected for heart rate, increased more rapidly with age in SCD patients and was higher in SCD than in control adults. cf-PWV and AI were independently associated with age, sex, height, heart rate, mean blood pressure, hemoglobin level, country, and hemoglobin phenotype. After adjustment for these correlates, cf-PWV and AI were associated with the glomerular filtration rate and osteonecrosis. AI was also associated with stroke, pulmonary hypertension, and priapism, and cf-PWV was associated with microalbuminuria.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>PWV and AI are deeply modified in SCD patients in comparison with healthy controls. These changes are independently associated with a lower blood pressure and a higher heart rate but also with the hemoglobin phenotype. Moreover, PWV and AI are associated with several SCD clinical complications. Their prognostic value will be assessed at follow-up of the patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.115.021015","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T02:33:11Z","timestamp":1472697191000},"page":"923-933","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Arterial Stiffness Impairment in Sickle Cell Disease Associated With Chronic Vascular Complications"],"prefix":"10.1161","volume":"134","author":[{"given":"Brigitte","family":"Ranque","sequence":"first","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Menet","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boutouyrie","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima Bara","family":"Diop","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kingue","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Diarra","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"N\u2019Guetta","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapa","family":"Diallo","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliou","family":"Diop","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Diagne","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Sanogo","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Tolo","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chelo","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Wamba","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cochise","family":"Abough\u2019elie","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheick Oumar","family":"Diakite","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssouf","family":"Traore","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Legueun","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indou","family":"Deme-Ly","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise Felix","family":"Faye","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); Physiology Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (P.B.); Cardiology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Seck","sequence":"additional","affiliation":[{"name":"From Internal Medicine Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Facult\u00e9 de m\u00e9decine, Universit\u00e9 Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des h\u00f4pitaux de l\u2019universit\u00e9 catholique de Lille, universit\u00e9 catholique de Lille, France (A.M.); 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