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In an era where a multitude of percutaneous solutions are emerging for the treatment of patients with heart failure, it becomes important to address the dynamic component of secondary MR during exercise as well. A critical reappraisal of the underlying disease mechanisms, in particular the dynamic component during exercise, is of timely importance. This review summarizes the pathophysiological mechanisms involved in the dynamic deterioration of secondary MR during exercise, its functional and prognostic impact, and the way current treatment options affect the dynamic lesion and exercise hemodynamics in general.<\/jats:p>","DOI":"10.1161\/circulationaha.116.025260","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T21:36:17Z","timestamp":1484602577000},"page":"297-314","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Exercise Dynamics in Secondary Mitral Regurgitation"],"prefix":"10.1161","volume":"135","author":[{"given":"Philippe B.","family":"Bertrand","sequence":"first","affiliation":[{"name":"From Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium (P.B.B., P.M.V.); Faculty of Medicine and Life Sciences, Hasselt University, Belgium (P.B.B., P.M.V.); Heart Center, Sheba Medical Center, Tel Hashomer, Israel (E.S.); 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