{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:23:37Z","timestamp":1792193017460,"version":"4.4.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2018,2,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Increased risk of dementia after myocardial infarction (MI) may be mediated by shared risk factors (eg, atherosclerosis) and post-MI stroke. We examined risk of dementia in 1-year survivors of MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using Danish medical registries, we conducted a nationwide population-based cohort study of all patients with first-time MI and a sex-, birth year\u2013, and calendar year\u2013matched general population comparison cohort without MI (1980\u20132012). Cox regression analysis was used to compute 1- to 35-year adjusted hazard ratios (aHRs) for dementia, controlled for matching factors and adjusted for comorbidities and socioeconomic status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 314\u2009911 patients with MI and 1\u2009573\u2009193 matched comparison cohort members randomly sampled from the general population (median age, 70 years; 63% male). After 35 years of follow-up, the cumulative incidence of all-cause dementia in the MI cohort was 9% (2.8% for Alzheimer disease, 1.6% for vascular dementia, and 4.5% for other dementias). Compared with the general population cohort, MI was not associated with all-cause dementia (aHR, 1.01; 95% confidence interval [CI], 0.98\u20131.03). Risk of Alzheimer disease (aHR, 0.92; 95% CI, 0.88\u20130.95) and other dementias (aHR, 0.98; 95% CI, 0.95\u20131.01) also approximated unity. However, MI was associated with higher risk of vascular dementia (aHR, 1.35; 95% CI, 1.28\u20131.43), which was substantially strengthened for patients experiencing stroke after MI (aHR, 4.48; 95% CI, 3.29\u20136.12).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MI was associated with higher risk of vascular dementia throughout follow-up, and this association was stronger in patients with stroke. The risk of Alzheimer disease and other dementias was not higher in patients with MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.117.029127","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T20:10:49Z","timestamp":1507839049000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Higher Risk of Vascular Dementia in Myocardial Infarction Survivors"],"prefix":"10.1161","volume":"137","author":[{"given":"Jens","family":"Sundb\u00f8ll","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"},{"name":"Department of Cardiology (J.S., K.A., M.S., H.E.B.), Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Horv\u00e1th-Puh\u00f3","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Adelborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"},{"name":"Department of Cardiology (J.S., K.A., M.S., H.E.B.), Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"},{"name":"Department of Cardiology (J.S., K.A., M.S., H.E.B.), Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (J.S., K.A., M.S., H.E.B.), Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"},{"name":"Departments of Health Research and Policy (Epidemiology) and Neurology and Neurological Sciences, Stanford University, CA (V.W.H., H.T.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Toft S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.)"},{"name":"Departments of Health Research and Policy (Epidemiology) and Neurology and Neurological Sciences, Stanford University, CA (V.W.H., H.T.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e356"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487313509495"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.1986"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013321"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015242"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2007.09.004"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.501106"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj025"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811408483"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/978-1-4757-3294-8","volume-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau T","year":"2000","unstructured":"Therneau T. 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