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Clinicians have a role to play in reducing the burden of pollution-attributable cardiovascular disease. However, there currently exists no clear clinical approach to this problem. Here, we provide a blueprint for an evidence-based clinical approach to assessing and mitigating cardiovascular risk from exposure to air pollution. We begin with a discussion of the global burden of pollution-attributable cardiovascular disease, including a review of the mechanisms by which particulate matter air pollution leads to cardiovascular outcomes. Next, we offer a simple patient-screening tool using known risk factors for pollution exposure. We then discuss approaches to quantifying air pollution exposures and cardiovascular risk, including the development of risk maps for clinical catchment areas. We review a collection of interventions for household and outdoor air pollution, which clinicians can tailor to patients and populations at risk. Finally, we identify future research needed to quantify pollution exposures and validate clinical interventions. Overall, we demonstrate that clinicians can be empowered to mitigate the global burden of cardiovascular disease attributable to air pollution.<\/jats:p>","DOI":"10.1161\/circulationaha.117.030377","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T15:43:48Z","timestamp":1518536628000},"page":"725-742","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["Developing a Clinical Approach to Air Pollution and Cardiovascular Health"],"prefix":"10.1161","volume":"137","author":[{"given":"Michael B.","family":"Hadley","sequence":"first","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (M.B.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Institute for Health and Social Policy and Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Quebec, Montreal, Canada (J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Vedanthan","sequence":"additional","affiliation":[{"name":"Institute for Health and Social Policy and Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Quebec, Montreal, Canada (J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"Institute for Health Metrics and Evaluation. 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