{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:07Z","timestamp":1790957647469,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2018,2,13]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We constructed a genetic risk score for high BP by using 314 published BP loci in 277\u2009005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Healthy lifestyle score was strongly associated with BP (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;10\n                      <jats:sup>\u2013320<\/jats:sup>\n                      ) for systolic and diastolic BP and CVD events regardless of the underlying BP genetic risk. Participants with a favorable in comparison with an unfavorable lifestyle (bottom versus top tertile lifestyle score) had 4.9, 4.3, and 4.1 mm\u2009Hg lower systolic BP in low, middle, and high genetic risk groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction=0.0006). Similarly, favorable in comparison with unfavorable lifestyle showed 30%, 33%, and 31% lower risk of CVD among participants in low, middle, and high genetic risk groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction=0.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our data further support population-wide efforts to lower BP in the population via lifestyle modification. The advantages and disadvantages of disclosing genetic predisposition to high BP for risk stratification needs careful evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.117.030898","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T05:30:13Z","timestamp":1513575013000},"page":"653-661","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":272,"title":["Genetic Predisposition to High Blood Pressure and Lifestyle Factors"],"prefix":"10.1161","volume":"137","author":[{"given":"Raha","family":"Pazoki","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"},{"name":"MRC-PHE Centre for Environment, School of Public Health, Imperial College London, United Kingdom (A.D., H.G., P.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"},{"name":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Warren","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (H.W., M.C.)"},{"name":"National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, United Kingdom (H.W., M.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"},{"name":"MRC-PHE Centre for Environment, School of Public Health, Imperial College London, United Kingdom (A.D., H.G., P.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Caulfield","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (H.W., M.C.)"},{"name":"National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, United Kingdom (H.W., M.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"},{"name":"MRC-PHE Centre for Environment, School of Public Health, Imperial College London, United Kingdom (A.D., H.G., P.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Tzoulaki","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Imperial College London, United Kingdom (R.P., A.D., E.E., H.G., P.E., I.T.)"},{"name":"MRC-PHE Centre for Environment, School of Public Health, Imperial College London, United Kingdom (A.D., H.G., P.E., I.T.)"},{"name":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E., I.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.82"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.008718"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3768"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.30000"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6939.1263"},{"key":"e_1_3_3_7_2","first-page":"1171","article-title":"Public health measures for blood pressure control in the whole community.","volume":"11","author":"Marmot MG","year":"1989","unstructured":"Marmot MG, Elliott P. Public health measures for blood pressure control in the whole community. Clin Exp Hypertens A. 1989;11:1171\u20131186.","journal-title":"Clin Exp Hypertens A"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.03.077"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70103-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834f1915"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt159"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7041.1249"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym276"},{"key":"e_1_3_3_14_2","unstructured":"UK Biobank Coordinating Centre. UK Biobank: Protocol for a large-scale prospective epidemiological resource. Protocol No: UKBB-PROT-09-06 (Main Phase). March 21 2007 (AMENDMENT ONE FINAL). http:\/\/www.ukbiobank.ac.uk\/wp-content\/uploads\/2011\/11\/UK-Biobank-Protocol.pdf; Accessed May 15 2017."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2165"},{"key":"e_1_3_3_17_2","unstructured":"Fry D Almond R Gordon M Moffat S. UK Biobank Biomarker Project Details of assays and quality control information for the urinary biomarker data. October 28 2016. http:\/\/biobank.ctsu.ox.ac.uk\/crystal\/refer.cgi?id=34972. Accessed May 15 2017."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_3_3_19_2","first-page":"82","article-title":"Diet and lifestyle recommendations revision 2006; a scientific statement from the American Heart Association Nutrition Committee.","volume":"114","author":"Lichtenstein AH","year":"2006","unstructured":"Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J. Diet and lifestyle recommendations revision 2006; a scientific statement from the American Heart Association Nutrition Committee. Arterioscler Thromb Vasc Biol. 2006;114:82\u201396.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.133603"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","unstructured":"Schnier C Sudlow C. Definitions of acute myocardial infarction (MI) and main MI pathological types for UK Biobank phase 1 outcomes adjudication. January 2017. http:\/\/biobank.ctsu.ox.ac.uk\/crystal\/docs\/alg_outcome_mi.pdf. Accessed July 15 2017.","DOI":"10.23889\/ijpds.v1i1.358"},{"key":"e_1_3_3_22_2","unstructured":"Genotype Imputation and Genetic Association Studies of UK Biobank: Interim Data Release. May 2015. http:\/\/www.ukbiobank.ac.uk\/wp-content\/uploads\/2014\/04\/imputation_documentation_May2015.pdf. Accessed May 17 2017."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/166298"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3715"},{"key":"e_1_3_3_25_2","unstructured":"Ahmad OB Boschi-Pinto C Lopez AD Murray CJ Lozano R Inoue M. Age Standardization of Rates: A New Who Standard. GPE Discussion Paper Series: No.31. EIP\/GPE\/EBD. World Health Organization 2001. http:\/\/www.who.int\/healthinfo\/paper31.pdf. Accessed July 28 2017."},{"key":"e_1_3_3_26_2","unstructured":"ISDScotland. GPD Support Population: Standard Population. http:\/\/www.isdscotland.org\/Products-and-Services\/GPD-Support\/Population\/Standard-Populations\/. Accessed July 28 2017."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706728"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00649"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801869"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605086"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw337"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.00948"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2012.668143"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2698"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2289"},{"key":"e_1_3_3_36_2","first-page":"77","article-title":"Regression dilution bias in blood pressure and body mass index in a longitudinal population-based cohort study.","volume":"15","author":"Masudi S","year":"2015","unstructured":"Masudi S, Yavari P, Mehrabi Y, Khalili D, Azizi F. Regression dilution bias in blood pressure and body mass index in a longitudinal population-based cohort study. J Res Health Sci. 2015;15:77\u201382.","journal-title":"J Res Health Sci"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117100"}],"updated-by":[{"DOI":"10.1161\/cir.0000000000000646","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000}}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.117.030898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T16:58:48Z","timestamp":1719680328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.117.030898"}},"subtitle":["Associations With Midlife Blood Pressure Levels and Cardiovascular Events"],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,2,13]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.117.030898"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.117.030898","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,13]]},"assertion":[{"value":"2017-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}