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The availability of different oral P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitors (clopidogrel, prasugrel, ticagrelor) has enabled physicians to contemplate switching among therapies because of specific clinical scenarios. The recent introduction of an intravenous P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitor (cangrelor) further adds to the multitude of modalities and settings in which switching therapies may occur. In clinical practice, it is not uncommon to switch P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitor, and switching may be attributed to a variety of factors. However, concerns about the safety of switching between these agents have emerged. Practice guidelines have not fully elaborated on how to switch therapies, leaving clinicians with limited guidance on when and how to switch therapies when needed. This prompted the development of this expert consensus document by key leaders from North America and Europe with expertise in basic, translational, and clinical sciences in the field of antiplatelet therapy. This expert consensus provides an overview of the pharmacology of P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitors, different modalities and definitions of switching, and available literature and recommendations for switching between P2Y\n                    <jats:sub>12<\/jats:sub>\n                    inhibitors.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.117.031164","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T19:30:12Z","timestamp":1509391812000},"page":"1955-1975","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":357,"title":["International Expert Consensus on Switching Platelet P2Y\n                    <sub>12<\/sub>\n                    Receptor\u2013Inhibiting Therapies"],"prefix":"10.1161","volume":"136","author":[{"given":"Dominick J.","family":"Angiolillo","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of Florida College of Medicine, Jacksonville (D.J.A., F.R., F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Rollini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Florida College of Medicine, Jacksonville (D.J.A., F.R., F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, United Kingdom (R.F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart &amp; Vascular Center, Harvard Medical School, Boston, MA (D.L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Sweden (S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiology Unit, Cardiovascular Research Institute, University of Vermont, Burlington (D.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Sibbing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany (D.S.)."},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Germany (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek Y.F.","family":"So","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada (D.Y.S.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Trenk","sequence":"additional","affiliation":[{"name":"Department of Cardiology &amp; Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany (D.T., W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, National and Capodistrian University of Athens, Attikon University Hospital, Greece (D. 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