{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:02:26Z","timestamp":1790557346620,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2018,1,30]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The Absorb bioresorbable vascular scaffold (BVS) completely resorbs within 3 years after coronary artery implantation. The safety and effectiveness of BVS through this critical 3-year period have not been characterized.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We performed an individual-patient-data pooled meta-analysis of the 4 randomized ABSORB trials in which 3389 patients with coronary artery disease were randomly assigned to everolimus-eluting Absorb BVS (n=2164) or cobalt-chromium everolimus-eluting stents (n=1225). The primary efficacy outcome measure was target lesion failure (cardiac mortality, target vessel myocardial infarction, or ischemia-driven target lesion revascularization), and the primary safety outcome measure was device thrombosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              BVS compared with cobalt-chromium everolimus-eluting stents resulted in higher 3-year rates of target lesion failure (11.7% versus 8.1%; risk ratio [RR], 1.38; 95% confidence interval [CI], 1.10\u20131.73;\n              <jats:italic>P<\/jats:italic>\n              =0.006), driven by greater target vessel myocardial infarction (7.8% versus 4.2%; RR, 1.72; 95% CI, 1.26\u20132.35;\n              <jats:italic>P<\/jats:italic>\n              =0.0006) and ischemia-driven target lesion revascularization (6.6% versus 4.4%; RR, 1.44; 95% CI, 1.05\u20131.98;\n              <jats:italic>P<\/jats:italic>\n              =0.02), with comparable cardiac mortality (1.1% versus 1.1%; RR, 0.93; 95% CI, 0.47\u20131.88;\n              <jats:italic>P<\/jats:italic>\n              =0.85). Device thrombosis rates through 3 years were also higher with BVS (2.4% versus 0.6%; RR, 3.71; 95% CI, 1.70\u20138.11;\n              <jats:italic>P<\/jats:italic>\n              =0.001). Between 1 and 3 years, target lesion failure rates (6.1% versus 3.9%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) and device thrombosis rates (1.1% versus 0.0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) were higher with BVS than cobalt-chromium everolimus-eluting stents.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In the present individual-patient-data pooled meta-analysis of the ABSORB trials, BVS was associated with increased rates of target lesion failure and device thrombosis between 1 and 3 years and cumulatively through 3 years of follow-up compared with everolimus-eluting stents.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifiers: NCT01751906, NCT01844284, NCT01923740, and NCT01425281.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.117.031843","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T18:30:33Z","timestamp":1509474633000},"page":"464-479","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["Three-Year Outcomes With the Absorb Bioresorbable Scaffold"],"prefix":"10.1161","volume":"137","author":[{"given":"Ziad A.","family":"Ali","sequence":"first","affiliation":[{"name":"New York\u2013Presbyterian Hospital\/Columbia University Medical Center, New York (Z.A.A., G.W.S.)"},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Z.A.A., G.W.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runlin","family":"Gao","sequence":"additional","affiliation":[{"name":"Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China (R.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Kyoto University Hospital, Japan (T.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (Y.O.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"The Christ Hospital, Heart and Vascular Center, Lindner Research Center, Cincinnati, OH (D.J.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, OH (S.G.E.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Institut Cardiovasculaire Paris Sud, Massy, France (B.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh-thien","family":"Vu","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (M.-t.V., Z.Z., C.A.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (M.-t.V., Z.Z., C.A.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Simonton","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (M.-t.V., Z.Z., C.A.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"International Centre for Cardiovascular Health, Imperial College, London, UK (P.W.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"New York\u2013Presbyterian Hospital\/Columbia University Medical Center, New York (Z.A.A., G.W.S.)"},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Z.A.A., G.W.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.097014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000064"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw343"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.07.009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.958249"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01039-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31470-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx155"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310275"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61455-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32050-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv435"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.054"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509038"},{"key":"e_1_3_3_17_2","article-title":"Everolimus-eluting bioresorbable vascular scaffolds in patients with coronary artery disease: ABSORB III trial 2-year results.","author":"Ellis SG","unstructured":"Ellis SG. 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