{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:44:17Z","timestamp":1792759457794,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Ventricular fibrillation (VF) storm after myocardial infarction (MI) is a life-threatening condition that necessitates multiple defibrillations. Catheter ablation is a potentially effective treatment strategy for VF storm refractory to optimal medical treatment. However, its impact on patient survival has not been verified in a large population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We conducted a multicenter, retrospective observational study involving consecutive patients who underwent catheter ablation of post-MI refractory VF storm without preceding monomorphic ventricular tachycardia. The target of ablation was the Purkinje-related ventricular extrasystoles triggering VF. The primary outcome was in-hospital and long-term mortalities. Univariate logistic regression and Cox proportional-hazards analysis were used to evaluate clinical characteristics associated with in-hospital and long-term mortalities, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              One hundred ten patients were enrolled (age, 65\u00b111years; 92 men; left ventricular ejection fraction, 31\u00b110%). VF storm occurred at the acute phase of MI (4.5\u00b12.5 days after the onset of MI during the index hospitalization for MI) in 43 patients (39%), the subacute phase (&gt;1 week) in 48 (44%), and the remote phase (&gt;6 months) in 19 (17%). The focal triggers were found to originate from the scar border zone in 88 patients (80%). During in-hospital stay after ablation, VF storm subsided in 92 patients (84%). Overall, 30 (27%) in-hospital deaths occurred. The duration from the VF occurrence to the ablation procedure was associated with in-hospital mortality (odds ratio for each 1-day increase, 1.11 [95% CI, 1.03\u20131.20];\n              <jats:italic>P<\/jats:italic>\n              =0.008). During follow-up after discharge from hospital, only 1 patient developed recurrent VF storm. However, 29 patients (36%) died, with a median survival time of 2.2 years (interquartile range, 1.2\u20135.5 years). Long-term mortality was associated with left ventricular ejection fraction &lt;30% (hazard ratio, 2.54 [95% CI, 1.21\u20135.32];\n              <jats:italic>P<\/jats:italic>\n              =0.014), New York Heart Association class \u2265III (hazard ratio, 2.68 [95% CI, 1.16\u20136.19];\n              <jats:italic>P<\/jats:italic>\n              =0.021), a history of atrial fibrillation (hazard ratio, 3.89 [95% CI, 1.42\u201310.67];\n              <jats:italic>P<\/jats:italic>\n              =0.008), and chronic kidney disease (hazard ratio, 2.74 [95% CI, 1.15\u20136.49];\n              <jats:italic>P<\/jats:italic>\n              =0.023).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In patients with MI presenting with focally triggered VF storm, catheter ablation of culprit triggers is lifesaving and appears to be associated with short- and long-term freedom from recurrent VF storm. Mortality over the long-term follow-up is associated with the severity of underlying cardiovascular disease and comorbidities in this specific patient population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.118.037997","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T09:00:39Z","timestamp":1554109239000},"page":"2315-2325","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["Catheter Ablation of Refractory Ventricular Fibrillation Storm After Myocardial Infarction"],"prefix":"10.1161","volume":"139","author":[{"given":"Yuki","family":"Komatsu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan (Y.K., A.N., K.A., M.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9l\u00e8ze","family":"Hocini","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (Centre Hospitalier Universitaire [CHU]), Electrophysiology and Ablation Unit, Pessac, France (M.H., A.D., M.H.)."},{"name":"Institut Hospitalo-Universitaire (IHU) Liryc, Electrophysiology and Heart Modeling Institute, Pessac-Bordeaux, France (M.H., A.D., M.H.)."},{"name":"University Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, France (M.H., A.D., M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan (Y.K., A.N., K.A., M.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[{"name":"Hospital Rangueil, Centre Hospitalier Universitaire Toulouse, France (P.M., Q.V.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Peichl","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic (P.P., D.W., J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (Y.-k.I., W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Heart Rhythm Management, Yokohama Rosai Hospital, Japan (K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Denis","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (Centre Hospitalier Universitaire [CHU]), Electrophysiology and Ablation Unit, Pessac, France (M.H., A.D., M.H.)."},{"name":"Institut Hospitalo-Universitaire (IHU) Liryc, Electrophysiology and Heart Modeling Institute, Pessac-Bordeaux, France (M.H., A.D., M.H.)."},{"name":"University Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, France (M.H., A.D., M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Voglimacci-Stephanopoli","sequence":"additional","affiliation":[{"name":"Hospital Rangueil, Centre Hospitalier Universitaire Toulouse, France (P.M., Q.V.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wichterle","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic (P.P., D.W., J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Showa University School of Medicine, Tokyo, Japan (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Fukamizu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, Japan (S.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Luke\u2019s International Hospital, Tokyo, Japan (Y.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan (T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Ibaraki Prefectural Central Hospital, Kasama, Japan (K.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryobun","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Division of Cardiovascular Center, Kinki University School of Medicine, Osaka, Japan (R.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Igawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tsukuba Memorial Hospital, Japan (M.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mito Saiseikai General Hospital, Japan (K.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (Y.-k.I., 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Multicenter Study"],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":28,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,5,14]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.118.037997"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.118.037997","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"2018-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}