{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:54:59Z","timestamp":1790704499773,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,3,17]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Long-term outcomes in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention with a drug-eluting stent are unclear. Therefore, we aimed to evaluate long-term adverse events in HBR patients undergoing percutaneous coronary intervention with cobalt-chromium everolimus-eluting stent implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We analyzed stratified data from 4 all-comers postapproval registries. Patients with at least 1 of the following criteria were categorized as HBR: age \u226575 years, history of major bleeding (MB), history of stroke, chronic oral anticoagulant use, chronic kidney disease, anemia, or thrombocytopenia. Additionally, in a separate analysis, patients were categorized according to the recently published Academic Research Consortium HBR criteria. The Kaplan-Meier method was used for time-to-event analyses. Coronary thrombotic events (CTE) included myocardial infarction or definite\/probable stent thrombosis. MB was defined according to the TIMI (Thrombolysis in Myocardial Infarction) or GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) scales. Impact of CTE and MB on subsequent risk of mortality was assessed using multivariable Cox regression with MB and CTE included as time-updated covariates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Of the total 10 502 patients included, 3507 (33%) were identified as HBR. Compared with non-HBR patients, those at HBR had more comorbidities, higher lesion complexity, and a higher risk of 4-year mortality (Hazard Ratio [HR] 4.38 [95% CI, 3.76\u20135.11]). Results were qualitatively similar when using Academic Research Consortium criteria to define HBR. Risk of mortality was increased after CTE (HR 5.02 [95% CI, 3.93\u20136.41]), as well as after MB (HR 4.92 [95% CI, 3.82\u20136.35]). Of note, this effect was consistent across the spectrum of bleeding risk (\n              <jats:italic>P<\/jats:italic>\n              -interaction test 0.97 and 0.06, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Compared with the non-HBR population, HBR patients experienced worse 4-year outcomes after percutaneous coronary intervention with cobalt-chromium everolimus-eluting stent. Both CTE and MB had a significant impact on subsequent risk of mortality irrespective of bleeding risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.119.041619","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T10:00:46Z","timestamp":1580292046000},"page":"891-901","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Long-Term Safety and Efficacy of Durable Polymer Cobalt-Chromium Everolimus-Eluting Stents in Patients at High Bleeding Risk"],"prefix":"10.1161","volume":"141","author":[{"given":"Sabato","family":"Sorrentino","sequence":"first","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimmer E.","family":"Claessen","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Chandiramani","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Guedeney","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Vogel","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinuta","family":"Rau","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (V.R., J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (V.R., J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Krucoff","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Teikyo University, Tokyo, Japan (K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University, Shanghai, People\u2019s Republic of China (J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Seth","sequence":"additional","affiliation":[{"name":"Fortis Escorts Heart Institute, New Delhi, India (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Los Angeles, CA (R. Makkar)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center (S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart &amp; Vascular Center, Harvard Medical School, Boston, MA (D.L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine-Jacksonville (D.J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Shonan Kamakura General Hospital, Japan (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"University of Freiburg, Germany (F.-J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hermiller","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Medical Center of Indiana, Indianapolis (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"Bern University Hospital, Switzerland (M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (S.S., B.E.C., R.C., P.G., B.V., U.B., Y.L., R. Mehran)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu366"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I9A159"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.064"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3775"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503943"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.11.015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1673687"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.03.038"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2014.03.007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-018-0515-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.08.010"},{"key":"e_1_3_3_13_2","volume-title":"Presented at China Interventional Therapeutics (CIT)","author":"Runlin G","unstructured":"Runlin, G. XIENCE V China RCT 2 Year Results. Presented at China Interventional Therapeutics (CIT). March 22, 2014. Shanghai, China."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz372"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq165"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.057"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.011"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.12.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32713-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.036"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.047"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.119.041619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:33:20Z","timestamp":1715589200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.119.041619"}},"subtitle":["A Patient-Level Stratified Analysis From Four Postapproval Studies"],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,3,17]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.119.041619"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.119.041619","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,17]]},"assertion":[{"value":"2019-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}