{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:22:06Z","timestamp":1790821326625,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2019,12,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The Absorb everolimus-eluting bioresorbable vascular scaffold (BVS) provides early drug delivery and mechanical support similar to those of metallic drug-eluting stents, followed by complete resorption in \u22483 years with recovery of vascular structure and function. The ABSORB III trial demonstrated noninferior rates of target lesion failure (cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization) at 1 year with BVS compared with cobalt chromium everolimus-eluting stents. Between 1 and 3 years and cumulative to 3 years, adverse event rates (particularly target vessel myocardial infarction and scaffold thrombosis) were increased after BVS. We sought to assess clinical outcomes after BVS through 5 years, including beyond the 3-year time point of complete scaffold resorption.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Clinical outcomes from ABSORB III were analyzed by randomized device (intention to treat) cumulative to 5 years and between 3 and 5 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Rates of target lesion failure, target vessel myocardial infarction, and scaffold thrombosis were increased through the 5-year follow-up with BVS compared with everolimus-eluting stents. However, between 3 and 5 years, reductions in the relative hazards of the BVS compared with everolimus-eluting stents were observed, particularly for target lesion failure (hazard ratio, 0.83 [95% CI, 0.55\u20131.24] versus 1.35 [95% CI, 1.02\u20131.78];\n              <jats:italic>P<\/jats:italic>\n              <jats:sup>int<\/jats:sup>\n              =0.052) and scaffold thrombosis (hazard ratio, 0.26 [95% CI, 0.02\u20132.87] versus 3.23 [95% CI, 1.25\u20138.30];\n              <jats:italic>P<\/jats:italic>\n              <jats:sup>int<\/jats:sup>\n              =0.056) compared with the 0- to 3-year time period.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In the ABSORB III trial, cumulative 5-year adverse event rates were increased after BVS compared with everolimus-eluting stents. However, the period of excess risk for BVS ended at 3 years, coincident with complete scaffold resorption.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01751906.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.119.042584","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T15:02:19Z","timestamp":1569423739000},"page":"1895-1903","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Clinical Outcomes Before and After Complete Everolimus-Eluting Bioresorbable Scaffold Resorption"],"prefix":"10.1161","volume":"140","author":[{"given":"Dean J.","family":"Kereiakes","sequence":"first","affiliation":[{"name":"The Christ Hospital Heart and Vascular Center, Lindner Research Center, Cincinnati, OH (D.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, OH (S.G.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Christopher","family":"Metzger","sequence":"additional","affiliation":[{"name":"Wellmont Holston Valley Medical Center, Kingsport, TN (D.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Caputo","sequence":"additional","affiliation":[{"name":"St. Joseph\u2019s Hospital Health Center, Liverpool, NY (R.P.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Rizik","sequence":"additional","affiliation":[{"name":"Scottsdale Healthcare, AZ (D.G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Teirstein","sequence":"additional","affiliation":[{"name":"Scripps Clinic, La Jolla, CA (P.S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Litt","sequence":"additional","affiliation":[{"name":"Baptist Medical Center, Jacksonville, FL (M.R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapoorna","family":"Kini","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York (A. Kini)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Kabour","sequence":"additional","affiliation":[{"name":"Mercy St. Vincent\u2019s Medical Center, Toledo, OH (A. Kabour)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven O.","family":"Marx","sequence":"additional","affiliation":[{"name":"New York Presbyterian Hospital, Columbia University Medical Center and the Cardiovascular Research Foundation (S.O.M., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Popma","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA (J.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siok Hwee","family":"Tan","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (S.H.T., D.E.E., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divine E.","family":"Ediebah","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (S.H.T., D.E.E., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Simonton","sequence":"additional","affiliation":[{"name":"Abbott Vascular, Santa Clara, CA (S.H.T., D.E.E., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"New York Presbyterian Hospital, Columbia University Medical Center and the Cardiovascular Research Foundation (S.O.M., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the ABSORB III Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.097014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.958249"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.054"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008152"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5208"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001790"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021539"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509038"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32050-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031843"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.07.013"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1203730"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6646-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.853"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.060"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.029"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.051"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.008"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.119.042584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:49:09Z","timestamp":1715586549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.119.042584"}},"subtitle":["Five-Year Follow-Up From the ABSORB III Trial"],"short-title":[],"issued":{"date-parts":[[2019,12,3]]},"references-count":21,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2019,12,3]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.119.042584"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.119.042584","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,3]]},"assertion":[{"value":"2019-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}